Insights From the International Registry of Acute Aortic Dissection A 20-Year Experience of Collaborative Clinical Research
Insights From the International Registry of Acute Aortic Dissection A 20-Year Experience of Collaborative Clinical Research
复制标题
DOI：
10.1161/circulationaha.117.031264
复制
发表时间：
2018-04-24
期刊：
影响因子：
37.8
通讯作者：
Eagle, Kim A.
中科院分区：
文献类型：
--
作者：
Evangelista, Arturo;Isselbacher, Eric M.;Eagle, Kim A.
急性主动脉夹层（AAD）是一种危及生命的疾病，发病率和死亡率很高，诊断和治疗仍然是一个挑战。急性主动脉夹层国际登记处成立于 1996 年，其使命是提高人们对这种疾病的认识并提供指导诊断和治疗的见解。自那时以来，已纳入来自 12 个国家超过 51 个地点的超过 7300 例病例。尽管在此期间出现的症状和体检结果没有显着变化，但计算机断层扫描在诊断中的使用有所增加，并且更多的患者接受介入治疗：A 型 AAD 进行手术，B 型 AAD 进行血管内治疗；随着护理方面的这些变化，A 型 AAD 的总体院内死亡率显着下降，但 B 型 AAD 的住院死亡率并未显着下降。在此，我们总结了过去 20 年从 AAD 患者国际登记中吸取的重要经验教训。
Acute aortic dissection (AAD) is a life-threatening condition associated with high morbidity and mortality rates, and it remains a challenge to diagnose and treat. The International Registry of Acute Aortic Dissection was established in 1996 with the mission to raise awareness of this condition and provide insights to guide diagnosis and treatment. Since then, >7300 cases have been included from >51 sites in 12 countries. Although presenting symptoms and physical findings have not changed significantly over this period, the use of computed tomography in the diagnosis has increased, and more patients are managed with interventional procedures: surgery in type A AAD and endovascular therapy in type B AAD; with these changes in care, there has been a significant decrease in overall in-hospital mortality in type A AAD but not in type B AAD. Herein, we summarized the key lessons learned from this international registry of patients with AAD over the past 20 years.