CXCL12 improves immune responses to neurotropic virus propagation in the CNS by attracting antibody secreting cells
CXCL12 improves immune responses to neurotropic virus propagation in the CNS by attracting antibody secreting cells
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DOI：
10.1016/j.vetimm.2012.08.003
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发表时间：
2012-11-15
影响因子：
1.8
通讯作者：
Umemura, Takashi
中科院分区：
文献类型：
--
作者：
Lee, Hyunkyoung;Sunden, Yuji;Umemura, Takashi
先前的研究表明，脑内免疫后CNS中趋化因子表达和抗体分泌细胞（ASC）募集的增加有助于抑制嗜神经病毒。在这项研究中，脑内注射趋化因子被用来研究趋化因子对控制嗜神经病毒的有用性。在体外趋化性试验和体内脑内注射趋化因子实验中，CXCL12和鸡尾酒趋化因子（CXCL9、10、12和13的混合物）比CXCL9、10和13更强烈地吸引抗原特异性ASC。用CXCL12和鸡尾酒趋化因子脑内预处理的小鼠在脑内感染狂犬病毒后显示出存活率增加。这些结果表明，脑内注射CXCL 12诱导ASC迁移，并抑制狂犬病病毒在中枢神经系统中的神经致病性。(C)2012 Elsevier B.V.保留所有权利。
A previous study showed that increases in chemokine expression and recruitment of antibody secreting cells (ASCs) in the CNS after intracerebral immunization contributed to the suppression of a neurotropic virus. In this study, intracerebral chemokine injection was used to investigate the usefulness of chemokines for controlling neurotropic viruses. Both CXCL12 and a cocktail chemokine (a mixture of CXCL9, 10,12 and 13) attracted antigen-specific ASCs more strongly than CXCL9, 10 and 13 in an in vitro chemotaxis assay and in vivo intracerebral chemokine injection experiments. Mice pre-treated intracerebrally with CXCL12 and the cocktail chemokine showed an increased survival rate after intracerebral infection with rabies virus. These results suggest that intracerebral CXCL12 injection induces the migration of ASCs and suppresses the neuropathogenicity of rabies virus in the CNS. (C) 2012 Elsevier B.V. All rights reserved.