INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR INCREASE PHOSPHORYLATION OF THE SMALL HEAT-SHOCK PROTEIN - EFFECTS IN FIBROBLASTS, HEP-G2 AND U937 CELLS
INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR INCREASE PHOSPHORYLATION OF THE SMALL HEAT-SHOCK PROTEIN - EFFECTS IN FIBROBLASTS, HEP-G2 AND U937 CELLS
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DOI：
10.1016/0014-5793(89)81671-0
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发表时间：
1989-12-04
期刊：
影响因子：
3.5
通讯作者：
SAKLATVALA, J
中科院分区：
文献类型：
--
作者：
KAUR, P;WELCH, WJ;SAKLATVALA, J
Interleukin 1α and tumour necrosis factor‐α stimulated phosphorylation of three 27 kDa phosphoproteins in MRC‐5 fibroblasts which was sustained for up to 2 h after adding the cytokines. All three phosphoproteins were immunoprecipitated by a specific antiserum to the small mammalian heat shock protein, hsp 27. The three phosphoproteins from stimulated or control cells contained phosphoserine but not phosphothreonine or phosphotyrosine. Similar increases in phosphorylation of immunoprecipitable 27 kDa proteins were seen in U937 cells stimulated by TNFα and Hep G2 cells stimulated by IL 1α.
