Impaired long-trace eyeblink conditioning in a Tg2576 mouse model of Alzheimer's disease
Impaired long-trace eyeblink conditioning in a Tg2576 mouse model of Alzheimer's disease
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DOI：
10.1016/j.neulet.2011.10.071
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发表时间：
2012-01-06
影响因子：
2.5
通讯作者：
Kirino, Yutaka
中科院分区：
文献类型：
--
作者：
Kishimoto, Yasushi;Oku, Ikuko;Kirino, Yutaka
眨眼条件反射已被用于评估人类神经退行性疾病（包括阿尔茨海默病（AD））的认知表现。在这里，我们测试和比较的延迟和长跟踪间隔（TI = 500毫秒）眨眼条件在Tg2576小鼠模型的AD，在3，6和12个月的年龄。Tg2576小鼠在6月龄时表现出明显的痕量条件反射损伤。相比之下，延迟条件反射在Tg2576小鼠中甚至在12个月时也没有受损。这些发现表明，长TI眨眼条件反射比延迟条件反射更容易导致Tg2576小鼠的年龄相关性认知衰退。长迹眨眼条件反射可能是检测AD小鼠模型早期认知功能障碍的潜在工具。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Eyeblink conditioning has been used for assessing cognitive performance in cases of human neurodegenerative diseases including Alzheimer's disease (AD). Here, we tested and compared the delay and long-trace interval (TI = 500 ms) eyeblink conditionings in a Tg2576 mouse model of AD, at the age of 3, 6, and 12 months. Tg2576 mice exhibited significant impairment in trace conditioning at 6 months of age. In contrast, delay conditioning was not impaired in Tg2576 mice even at 12 months. These findings indicate that the long-TI eyeblink conditioning is more susceptible to age-related cognitive deterioration than delay conditioning in Tg2576 mice. The long-trace eyeblink conditioning could be a potential tool for detecting early cognitive deficits in AD mouse model. (C) 2011 Elsevier Ireland Ltd. All rights reserved.