New Data-Driven Gated PET/CT Free of Misregistration Artifacts.
New Data-Driven Gated PET/CT Free of Misregistration Artifacts.
复制标题
DOI：
10.1016/j.ijrobp.2020.11.014
复制
发表时间：
2021-04-01
期刊：
影响因子：
--
通讯作者：
Luo D
中科院分区：
文献类型：
--
作者：
Pan T;Lu Y;Thomas MA;Liao Z;Luo D
我们开发了一种新的数据驱动门控（DDG）正电子发射断层扫描（PET）/计算机断层扫描（CT），以改善CT和DDG PET的配准。我们采集了10次重复PET/CT和35次电影CT扫描，以缓解CT和PET数据之间的配准不良。我们还推导了呼气末相CT作为DDG CT，用于DDG PET的衰减校正。在重复PET/CT和电影CT之间比较辐射暴露、体重指数（BMI）、扫描覆盖范围和有效辐射剂量。在35例电影CT患者中，在平均PET/CT（通过平均CT进行基线PET衰减校正）、DDG PET（通过基线CT进行DDG PET衰减校正）和DDG PET/CT（通过DDG CT进行DDG PET衰减校正）之间比较了14例（共捕获59个肿瘤）的配准和定量，而不增加DDG PET的扫描时间。与重复PET/CT相比，电影CT的扫描覆盖范围（32.5 ± 11.5 cm vs 15.4 ± 4.7 cm; P <0.001）和有效辐射剂量（3.7 ± 2.6 mSv vs 1.3 ± 0.6 mSv; P <0.01）明显较低。重复PET/CT和电影CT在BMI或辐射暴露方面没有显著差异（P > 0.1）。电影CT节省了扫描时间，无需重复PET。平均PET/CT、DDG PET和DDG PET/CT与基线PET/CT的SUV比值分别为1.14 ± 0.28、1.28 ± 0.20和1.63 ± 0.64（P < .0001），表明SUVmax从基线PET/CT至平均PET/CT、DDG PET和DDG PET/CT连续增加。DDG PET的运动校正对量化的影响大于平均CT的配准改善。量化方面的最大改进来自DDG PET/CT，其中配准得到改善，运动得到缓解。我们新的DDG PET/CT方法消除了配准不良伪影，与DDG PET相比，改善了量化和配准。与重复CT相比，在我们的DDG PET/CT方法中使用电影CT也降低了有效辐射剂量和扫描覆盖范围。爱思唯尔公司出版
We developed a new data-driven gated (DDG) positron emission tomography (PET)/computed tomography (CT) to improve the registration of CT and DDG PET. We acquired 10 repeat PET/CT and 35 cine CT scans for the mitigation of misregistration between CT and PET data. We also derived end-expiration phase CT as DDG CT for attenuation correction of DDG PET. Radiation exposure, body mass index (BMI), scan coverage, and effective radiation dose were compared between repeat PET/CT and cine CT. Of the 35 cine CT patients, 14 (capturing 59 total tumors) were compared among average PET/CT (baseline PET attenuation correction by average CT), DDG PET (DDG PET attenuation correction by baseline CT), and DDG PET/CT (DDG PET attenuation correction by DDG CT) for registration and quantification without increasing the scan time for DDG PET. Compared with repeat PET/CT, cine CT had significantly lower scan coverage (32.5 ± 11.5 cm vs 15.4 ± 4.7 cm; P < .001) and effective radiation dose (3.7 ± 2.6 mSv vs 1.3 ± 0.6 mSv; P <.01). Repeat PET/CT and cine CT did not differ significantly in BMI or radiation exposure (P > .1). Cine CT saved the scan time for not needing a repeat PET. The SUV ratios of average PET/CT, DDG PET, and DDG PET/CT to baseline PET/CT were 1.14 ± 0.28, 1.28 ± 0.20, and 1.63 ± 0.64, respectively (P < .0001), suggesting that the SUVmax increased consecutively from baseline PET/CT to average PET/CT, DDG PET, and DDG PET/CT. Motion correction with DDG PET had a larger impact on quantification than registration improvement with average CT did. The biggest improvement in quantification was from DDG PET/CT, in which both registration was improved and motion was mitigated. Our new DDG PET/CT approach alleviates misregistration artifacts and, compared with DDG PET, improves quantification and registration. The use of cine CT in our DDG PET/CT method also reduces the effective radiation dose and scan coverage compared with repeat CT. Published by Elsevier Inc.
登录
查看更多内容
影响因子：
3.5
作者：
Carnes, Greg;Gaede, Stewart;Lee, Ting-Yim
通讯作者：
Lee, Ting-Yim
影响因子：
9.3
作者：
Hamill, James J.;Meier, Joseph G.;Mawlawi, Osama
通讯作者：
Mawlawi, Osama
影响因子：
4
作者：
Liu F;Jang H;Kijowski R;Zhao G;Bradshaw T;McMillan AB
通讯作者：
McMillan AB
DOI：
10.2967/jnumed.109.068759
发表时间：
2010-01
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Chang G;Chang T;Pan T;Clark JW Jr;Mawlawi OR
通讯作者：
Mawlawi OR
影响因子：
3.1
作者：
Boellaard, R.;Hofman, M. B. M.;Lammertsma, A. A.
通讯作者：
Lammertsma, A. A.