Fatigue in Parkinson's disease is not related to excessive sleepiness or quality of sleep
Fatigue in Parkinson's disease is not related to excessive sleepiness or quality of sleep
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DOI：
10.1016/j.jns.2008.02.013
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发表时间：
2008-07-15
影响因子：
4.4
通讯作者：
Groothoff, Johan W.
中科院分区：
文献类型：
--
作者：
Havlikova, Eva;van Dijk, Jitse P.;Groothoff, Johan W.
目的：许多帕金森病 (PD) 患者患有非运动症状，如睡眠障碍、白天过度嗜睡和疲劳。我们研究的目的是探讨疲劳是否与嗜睡和睡眠问题、抑郁和功能状态相关，并控制年龄、性别和病程。方法：样本由来自斯洛伐克东部的 78 名 PD 患者组成（52% 为男性，平均年龄 68.8 +/- 8.7，平均病程 7.2 +/- 6.8）。使用多维疲劳量表（5 个维度）、Epworth 嗜睡量表、匹兹堡睡眠质量指数、医院焦虑和抑郁量表以及统一帕金森病评定量表。人口统计数据是通过结构化访谈获得的。使用多元线性回归来分析数据。结果：在任何疲劳领域，嗜睡与疲劳均未显示出显着关联；睡眠质量也没有。抑郁与疲劳的所有领域均显着相关，其中与一般疲劳 (beta .42)、动机降低 (beta.39)、精神疲劳 (beta.35) 的关系最强 (p
Objectives: Many patients with Parkinson's disease (PD) suffer from non-motor symptoms like sleep disturbances, excessive daytime sleepiness and fatigue. The aim of our research was to explore whether fatigue is related to sleepiness and sleep problems, depression and functional status, controlled for age, gender and disease duration.Methods: The sample consisted of 78 PD patients from Eastern Slovakia (52% males, mean age 68.8 +/- 8.7, mean disease duration 7.2 +/- 6.8). The Multidimensional Fatigue Inventory (5 dimensions), the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index, Hospital Anxiety and Depression Scale and the Unified Parkinson's Disease Rating Scale were used. Demographic data were obtained in a structured interview. Multiple linear regression was used to analyse the data.Results: Sleepiness did not show significant association with fatigue in any of the fatigue domains; neither did quality of sleep. Depression was significantly associated with all domains of fatigue, the strongest being the relationship with general fatigue (beta .42), reduced motivation (beta.39), mental fatigue (beta.35) (p