Ectodomain shedding of receptor activator of NF-kappaB ligand.
Ectodomain shedding of receptor activator of NF-kappaB ligand.
复制标题
NF-κB 配体受体激活剂的胞外域脱落。
DOI：
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发表时间：
2007
影响因子：
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通讯作者：
Sakae Tanaka
中科院分区：
文献类型：
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作者：
Atsuhiko Hikita;Sakae Tanaka
破骨细胞生成的关键调节因子NF-κ B配体受体激活因子（RANKL）被蛋白水解加工并转化为可溶性形式。RANKL脱落酶和RANKL脱落的生物学和病理学作用尚未确定，但脱落酶的身份及其对破骨细胞生成的影响逐渐澄清。调节机制及其与某些病理条件的相关性有待阐明。
Receptor activator of NF-kappab ligand (RANKL), a key regulator of osteoclastogenesis, is proteolytically processed and converted to a soluble form. RANKL sheddase and the biologic and pathologic role of RANKL shedding have been undetermined, but the identity of sheddase and its effect on osteoclastogenesis are gradually clarified. The regulatory mechanism and its relevance to some pathologic conditions are to be elucidated.