Prestimulus effects on startle magnitude: sensory or motor?
Prestimulus effects on startle magnitude: sensory or motor?
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刺激前对惊吓程度的影响：感觉还是运动？
DOI：
10.1037//0735-7044.116.4.672
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发表时间：
2002
影响因子：
1.9
通讯作者：
Geyer,MarkA
中科院分区：
文献类型：
--
作者：
Swerdlow,NealR;Shoemaker,JodyM;Stephany,Nora;Wasserman,Lindsay;Ro,HyunJ;Geyer,MarkA
当惊吓事件之前有刺激时，惊吓可能会受到抑制;当前刺激较弱且不惊吓时，这被称为前脉冲抑制（PPI）;当前刺激惊吓时，这被称为成对脉冲抑制（S1）。作者研究了不同物种之间这些测量的关系，并测试了配对脉冲抑制（如PPI）是否独立于刺激前的惊人效应。PPI（S-S1配置）和成对脉冲抑制（S1-S2配置）在1个测试中，在大鼠和人类中使用类似的刺激参数引起。在大鼠和人类的受试者中，PPI和成对脉冲抑制的量显著相关。当S1的惊人效应被弱前脉冲（s-S1-S2构型）消除时，配对脉冲抑制并没有减弱，当这些前脉冲效应被多巴胺激动剂阿扑吗啡消除时（在大鼠中），配对脉冲抑制也没有增强。尽管在介导PPI和成对脉冲抑制的抑制过程中存在明显差异，但两者都独立于对刺激前的运动反应。
Startle may be inhibited when the startling event is preceded by a stimulus; this is called prepulse inhibition (PPI) when the prestimulus is weak and nonstartling (s) and paired pulse inhibition when the prestimulus elicits startle (S1). The authors examined the relationship of these measures across species and tested whether paired pulse inhibition—like PPI—is independent of the startling effects of the prestimulus. PPI (s-S1 configuration) and paired pulse inhibition (S1-S2 configuration) were elicited in 1 test, using similar stimulus parameters in rats and humans. The amount of PPI and paired pulse inhibition was significantly correlated within subjects in both rats and humans. Paired pulse inhibition was not diminished when the startling effects of S1 were eliminated by a weak prepulse (s-S1-S2 configuration), nor was it enhanced when these prepulse effects were eliminated by the dopamine agonist apomorphine (in rats). Despite apparent differences in the inhibitory processes mediating PPI and paired pulse inhibition, both are independent of the motoric response to the prestimulus.