Recent Advances in the Regulation of Feeding Behavior by Neuropeptides in Fish
Recent Advances in the Regulation of Feeding Behavior by Neuropeptides in Fish
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DOI：
10.1111/j.1749-6632.2008.03619.x
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Matsuda, Kouhei
中科院分区：
文献类型：
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作者：
Matsuda, Kouhei
脊椎动物的下丘脑和脑干在摄食调节中起着重要作用。多种神经肽参与了啮齿动物摄食和能量平衡的调节。然而，除了啮齿类动物外，金鱼还被广泛用作动物模型来研究神经肽对摄食行为的影响。尽管几种神经肽对金鱼和啮齿类动物的摄食行为有相似的影响，但据报道，其他神经肽的作用存在显著差异。例如，在啮齿类动物中发挥食欲活性的黑色素浓缩激素，在金鱼中通过神经元相互作用的α-黑素细胞刺激素信号通路作为厌食神经肽。这些观察表明，虽然同一系列神经肽及其受体系统参与控制整个脊椎动物门的取食行为，但它们的作用模式在鱼类和哺乳动物之间可能存在重大差异。本文综述了神经肽在鱼类摄食行为调控中的最新研究进展，重点介绍了金鱼的最新研究进展。
The hypothalamus and brain stem in vertebrates play an important role in feeding regulation. Many kinds of neuropeptides have been implicated in the regulation of food intake and energy homeostasis in rodents. In addition to rodents, however, the goldfish has been widely used as an animal model to investigate the effects of neuropeptides on feeding behavior. Although several neuropeptides exert similar effects on feeding behavior in goldfish and in rodents, marked differences have been reported for other neuropeptides. For instance, melanin-concentrating hormone, which exerts orexigenic activity in rodents, acts as an anorexigenic neuropeptide via the alpha-melanocyte-stimulating hormone signaling pathway by neuronal interaction in goldfish. These observations indicate that, while the same series of neuropeptides and their receptor systems are involved in the control of feeding behavior throughout the vertebrate phylum, major differences may occur in their mode of action between fish and mammals. This paper gives a mini review of recent advances in the regulation of feeding behavior by neuropeptides in fish, with a focus on recent studies in goldfish.