BURST DISCHARGE IN MAMMALIAN NEUROENDOCRINE CELLS INVOLVES AN INTRINSIC REGENERATIVE MECHANISM
BURST DISCHARGE IN MAMMALIAN NEUROENDOCRINE CELLS INVOLVES AN INTRINSIC REGENERATIVE MECHANISM
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DOI：
10.1126/science.6879204
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
DUDEK, FE
中科院分区：
文献类型：
--
作者：
ANDREW, RD;DUDEK, FE
哺乳动物神经内分泌细胞的细胞内记录表明，稳定的注入电流可以改变和阻止先前与神经激素释放增加相关的周期性尖峰爆发。尖峰后电位可以相加形成平台电位，它产生爆发并且不依赖于轴突传导或化学突触。因此，爆发涉及单个神经内分泌细胞内源性的尖峰依赖性正反馈机制。
Intracellular recordings from mammalian neuroendocrine cells showed that steady, injected currents can modify and block periodic spike bursts previously associated with increased neurohormone release. Spike afterpotentials could sum to form plateau potentials, which generated bursts and did not depend on axonal conduction or chemical synapses. Therefore, bursting involves a spike-dependent, positive-feedback mechanism endogenous to single neuroendocrine cells.