Environmental tobacco smoke exposure during childhood is associated with increased prevalence of asthma in adults
Environmental tobacco smoke exposure during childhood is associated with increased prevalence of asthma in adults
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DOI：
10.1378/chest.120.3.711
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发表时间：
2001-09-01
期刊：
影响因子：
9.6
通讯作者：
Lundbäck, B
中科院分区：
文献类型：
--
作者：
Larsson, ML;Frisk, M;Lundbäck, B
目的：研究儿童时期暴露于环境烟草烟雾（ETS）是否对成人哮喘患病率有影响，并确定城市人群中ETS和其他下呼吸道刺激物（LAWI）的滋扰量。设计：一项邮政调查。地点：瑞典Orebro市，参与者：共8,008名随机选择的15 - 69岁的居民。测量：暴露，气道症状和呼吸史进行了评估，采用问卷调查。结果：应答率为84%。在儿童期暴露于ETS的从不吸烟者中，医生诊断的哮喘患病率为7.6%，而非暴露受试者为5.9%（p = 0.036）。在无哮喘家族史的从不吸烟者中，报告儿童期ETS暴露的受试者中医生诊断的哮喘患病率为6.8%，而非暴露受试者为3.8%（p < 0.001）。儿童时期暴露于ETS的受试者更有可能在成年后开始吸烟。在非暴露受试者中，曾经吸烟者的患病率为54.5% vs 33.8%（p < 0.0001）。ETS是总样本中最常见的LAWI（21%），其次是在冷空气中运动（20%）;灰尘（19%），运动（16%），香水（15%），冷空气（12%），花粉（10%）和宠物（8%）。所有LAWI更频繁地报告women.Conclusions：儿童暴露于ETS与成人从不吸烟者哮喘患病率增加，特别是在nonatopic科目。暴露于ETS的儿童也更有可能成为吸烟者。ETS是一个主要的LAWI。
Objective: To examine if exposure to environmental tobacco smoke (ETS) during childhood has an impact on asthma prevalence in adults, and to identify the amount of nuisance from ETS and other lower airway irritants (LAWIs) in a city population.Design: A postal survey. Setting: The municipality of Orebro, Sweden.Participants: A total of 8,008 randomly selected inhabitants aged 15 to 69 years. Measurements: Exposures, airway symptoms, and respiratory history were assessed using a questionnaire.Results: The response rate was 84%. In never-smokers with childhood ETS exposure, the prevalence of physician-diagnosed asthma was 7.6% vs 5.9% in nonexposed subjects (p = 0.036). In never-smokers without a family history of asthma, the prevalence of physician-diagnosed asthma in subjects reporting childhood ETS exposure was 6.8% vs 3.8% in nonexposed subjects (p < 0.001). Subjects with childhood ETS exposure were more likely to start smoking in adulthood. The prevalence of ever-smokers was 54.5% vs 33.8% (p < 0.0001) in nonexposed subjects. ETS was the most commonly reported LAWI in the total sample (21%), followed by exercise in cold air (20%); dust (19%), exercise (16%), perfume (15%), cold air (12%), pollen (10%), and pets (8%). All LAWIs were more frequently reported by women.Conclusions: Childhood exposure to ETS is associated with an increased prevalence of asthma among adult never-smokers, especially in nonatopic subjects. Children exposed to ETS are also more likely to become smokers. ETS is as a major LAWI.