The demonstration of pericryptal fibroblasts in background mucosa and dysplasia complicating ulcerative colitis
The demonstration of pericryptal fibroblasts in background mucosa and dysplasia complicating ulcerative colitis
复制标题
溃疡性结肠炎背景粘膜及发育异常中隐窝周围成纤维细胞的表现
DOI：
10.1046/j.1365-2559.1996.d01-437.x
复制
发表时间：
1996
期刊：
影响因子：
6.4
通讯作者：
I. Talbot
中科院分区：
文献类型：
--
作者：
T. Yao;I. Talbot
应用α -平滑肌肌动蛋白单克隆抗体，通过免疫组化方法研究了溃疡性结肠炎背景黏膜和异常增生中结膜周围成纤维细胞的存在。68个非发育不良粘膜切片中有18个（26%）的成纤维细胞减少。这种减少与杯状细胞耗竭和绒毛变化显著相关。在发育不良的粘膜中，成纤维细胞更常减少（50%），绒毛状的减少比非绒毛状的减少更大。成纤维细胞的发育与发育不良的级别（低级别或高级别）、与癌的距离（邻近或远离癌）或生长模式（息肉样或非息肉样）无关。这些研究结果表明：1 .背景粘膜中成纤维细胞的减少可能与溃疡性结肠炎中发育不良的发展有关；2 .与发育不良相似，绒毛再生过程中成纤维细胞的减少强化了绒毛改变可能是溃疡性结肠炎中癌症发展风险标志的假设。
The demonstration of pericryptal fibroblasts in background mucosa and dysplasia in ulcerative colitis was investigated by immunohistochemistry using monoclonal antibody for alpha‐smooth muscle actin. Pericryptal fibroblasts were reduced in 18 (26%) of the 68 sections of non‐dysplastic mucosa. The reduction was significantly correlated with goblet cell depletion and villous change. Pericryptal fibroblasts were more frequently reduced (50%) in dysplastic mucosa, the reduction being greater in villous than in non‐villous dysplasia. Pericryptal fibroblast development was not related to grade of dysplasia (low or high‐grade), distance from carcinoma (adjacent to or distant from carcinoma) or growth pattern (polypoid or non‐polypoid). These findings suggest that: 1 reduction of pericryptal fibroblasts in background mucosa may relate to the development of dysplasia in ulcerative colitis, 2 reduction of pericryptal fibroblasts in villous regeneration, analogous to that in dysplasia, reinforces the hypothesis that villous change may be a marker for risk of development of carcinoma in ulcerative colitis.
通过聚合酶链式反应产物的直接测序测定人胃肠道发育不良中 c-Ki-ras 的激活。
影响因子：
11.2
作者：
Meltzer,SJ;Mane,SM;Wood,PK;Resau,JH;Newkirk,C;Terzakis,JA;Korelitz,BI;Weinstein,WM;Needleman,SW
通讯作者：
Needleman,SW