COMPARATIVE EFFECTS OF THE ACTH 4-9 ANALOG (ORG 2766), ACTH 4-10 AND [D-PHE7] ACTH 4-10 ON MEDIAL SEPTAL SELF-STIMULATION BEHAVIOR IN RATS
COMPARATIVE EFFECTS OF THE ACTH 4-9 ANALOG (ORG 2766), ACTH 4-10 AND [D-PHE7] ACTH 4-10 ON MEDIAL SEPTAL SELF-STIMULATION BEHAVIOR IN RATS
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DOI：
10.1016/0028-3908(82)90083-1
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发表时间：
1982-01-01
影响因子：
4.7
通讯作者：
DEWIED, D
中科院分区：
文献类型：
--
作者：
FEKETE, M;BOHUS, B;DEWIED, D
Experiments were performed to examine the effects of various analogs of ACTH on electrical self-stimulation behavior elicited from the medial septal area using an ascending or descending sequence of stimulus intensities within a session. When an ascending sequence of threshold multiples was used, ACTH 4-10 and the ACTH 4-9 analog (ORG 2766) enhanced lever pressing for low intensity stimulation but attenuated self-stimulation at greater current intensities. The analog ORG 2766 appeared to be a thousand times more potent than ACTH 4-10; [D-Phe7]ACTH 4-10 inhibited the response rate at threshold level but was inactive at greater current intensities. The same effect was found following administration of ORG 2766 in a dose which was 20 times greater (1 .mu.g/rat) than that used in the first experiments. Lever pressing was not affected by treatment with ACTH 4-10 or ORG 2766 when a descending sequence of stimulus intensities was used within a session. Thus, ACTH-related peptides may affect motivational processes involved in self-stimulation rather than the reward of the stimulation per se. Although ORG 2766 mimicked the action of ACTH 4-10, this synthetic peptide may have additional behavioral properties.
