CEREBRAL CORTICAL GLUCOSE-UTILIZATION IN THE CONSCIOUS RAT - EVIDENCE FOR A CIRCADIAN-RHYTHM
CEREBRAL CORTICAL GLUCOSE-UTILIZATION IN THE CONSCIOUS RAT - EVIDENCE FOR A CIRCADIAN-RHYTHM
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DOI：
10.1111/j.1471-4159.1980.tb11263.x
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发表时间：
1980-01-01
影响因子：
4.7
通讯作者：
OLDENDORF, WH
中科院分区：
文献类型：
--
作者：
CRANE, PD;BRAUN, LD;OLDENDORF, WH
葡萄糖利用的昼夜节律存在于体内大鼠大脑皮层。老鼠生活在受控的光照环境中，从早上7点到晚上9点，老鼠的活动模式似乎与大脑中葡萄糖消耗的速度一致。全天每隔3小时测量一次利用率。它从0300时的最高点0.98 +-下跌。0.13 .mu。Mol /min g，最低0.70±。0.08 .mu。脑葡萄糖随时间变化，其波动水平与其利用率呈弱相关。喂食5小时（1630-2130小时）的动物也有类似的昼夜节律，只是幅度略有增加。光周期的逆转导致正常节律的中断，但利用仍然随着一天中的时间而显着变化。在一天的不同时间做的实验存在潜在的误差。需要意识到一天的时间作为一个因素在测量大脑代谢率的变化是强调。
The presence of a circadian rhythm of glucose utilization was demonstrated in vivo in rat cerebral cortex. The activity pattern of the rats, living in a controlled lighting regimen with lights on from 0700-1900 h, appeared to coincide with the rate of glucose consumption in the brain. The rate of utilization was measured at 3 h intervals throughout the day. It fell from a maximum at 0300 h of 0.98 .+-. 0.13 .mu.mol/min g to a minimum of 0.70 .+-. 0.08 .mu.mol/min g at 1500 h. Brain glucose varied with time and its fluctuating level weakly correlated with its rate of utilization. Animals entrained on a 5 h (1630-2130 h) feeding schedule had a similar circadian rhythm, with only a slight increase in amplitude. Reversal of the light cycle caused a disruption in the normal rhythm, but utilization still varied significantly with time of day. Potential error exists for experiments done at different times of the day. The need for awareness of time of day as a factor in measurements of alterations of metabolic rate in the brain is stressed.