Changes in substantia nigra and locus coeruleus in patients with early-stage Parkinson's disease using neuromelanin-sensitive MR imaging
Changes in substantia nigra and locus coeruleus in patients with early-stage Parkinson's disease using neuromelanin-sensitive MR imaging
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DOI：
10.1016/j.neulet.2013.02.012
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发表时间：
2013-04-29
影响因子：
2.5
通讯作者：
Terayama, Yasuo
中科院分区：
文献类型：
--
作者：
Ohtsuka, Chigumi;Sasaki, Makoto;Terayama, Yasuo
神经黑色素敏感磁共振成像能够可视化帕金森病（PD）患者黑质致密部（SNc）和蓝斑（LC）中神经元丢失相关的变化。然而，这种技术在帕金森病早期诊断的准确性仍然未知。因此，通过神经黑色素成像观察到的SNc和LC的变化在早期PD患者中被评估。测量SNc外侧、中央、内侧和LC的信号强度，并计算其与相邻白质结构的对比度（CRs）。与对照组相比，早期PD组SNc外侧部分和LC的cr显著降低。区分早期PD患者与健康对照的敏感性和特异性在外侧SNc中分别为73%和87%，在LC中分别为82%和90%。神经黑色素成像可以描述PD患者SNc外侧部分和LC的信号改变，甚至在其早期阶段，并且可以以高灵敏度和特异性区分这些患者和健康个体。2013爱思唯尔爱尔兰有限公司版权所有。
Neuromelanin-sensitive magnetic resonance imaging is able to visualize changes associated with neuronal loss in the substantia nigra pars compacta (SNc) and locus coeruleus (LC) in patients with Parkinson's disease (PD). However, the diagnostic accuracy of this technique in the early stages of PD remains unknown. Therefore, changes in the SNc and LC observed using neuromelanin imaging were evaluated in patients with early PD. The signal intensities of the lateral, central, and medial parts of the SNc and that of the LC were measured, and the contrast ratios (CRs) were calculated against the adjacent white matter structures. CRs in the lateral part of the SNc and in the LC were significantly reduced in the early PD group when compared with the controls. Sensitivities and specificities in discriminating early PD patients from healthy controls were 73% and 87% in lateral SNc and 82% and 90% in LC, respectively. Neuromelanin imaging can depict signal alterations in the lateral part of the SNc and in the LC in patients with PD, even in its early stage, and can discriminate between these patients and healthy individuals with high sensitivities and specificities. (C) 2013 Elsevier Ireland Ltd. All rights reserved.