Effect of Folic Acid Supplementation on Homocysteine, Serum Total Antioxidant Capacity, and Malondialdehyde in Patients with Type 2 Diabetes Mellitus
Effect of Folic Acid Supplementation on Homocysteine, Serum Total Antioxidant Capacity, and Malondialdehyde in Patients with Type 2 Diabetes Mellitus
复制标题
DOI：
10.1080/07315724.2011.10719962
复制
发表时间：
2011-06-01
影响因子：
3.5
通讯作者：
Aliasgharzadeh, Akbar
中科院分区：
文献类型：
--
作者：
Aghamohammadi, Vahide;Gargari, Bahram Pourghassem;Aliasgharzadeh, Akbar
目的：二甲双胍广泛用于2型糖尿病患者，但可降低维生素B12和叶酸水平，升高同型半胱氨酸(Hcy)水平。高同型半胱氨酸血症(HHC)和高血糖导致2型糖尿病的氧化应激。因此，本研究旨在研究补充叶酸对同型半胱氨酸浓度、总抗氧化能力(TAC)和丙二醛(MDA)的影响。68名2型糖尿病男性患者在获得书面同意的情况下参与了这项研究。患者随机分为叶酸5 mg/d组和安慰剂组。所有患者均服药8周。每个患者的人体测量和营养素摄入量数据都是从他们那里获得的。结果：叶酸组补充叶酸后，同型半胱氨酸水平显著降低(P<0.001)，叶酸和B12水平显著升高(P<0.001)。叶酸组的总抗氧化能力显著增加(0.96+/-0.2mmolFe2+/L至1.14+/-0.3mmolFe2+/L，p<；0.001)，丙二醛显著降低(2.6mU/-0.7mU/L，p<；0.001)，而安慰剂组则无明显变化(p>；结论：药物剂量的叶酸补充降低了2型糖尿病患者血浆同型半胱氨酸和血清丙二醛水平，改善了血清总抗氧化能力以及叶酸和B12水平。
Objective: Metformin is widely used in patients with type 2 diabetes, but it may decrease vitamin B12 and folate levels and increase levels of homocysteine (Hcy). Hyperhomocysteinemia (HHC) and hyperglycemia induce oxidative stress in type 2 diabetes. Thus, this study was performed to determine the effects of folate supplementation on the concentration of homocysteine, total antioxidant capacity (TAC), and malondialdehyde (MDA).Methods: This was a double-blind randomized controlled clinical trial. Sixty-eight men with type 2 diabetes participated in the study with written consent. Patients were divided randomly into 2 groups: folic acid 5 mg/d and placebo. All patients received the tablets for 8 weeks. Anthropometric and nutrient intake data were obtained from each patient. Baseline and eighth-week homocysteine, total antioxidant capacity, malondialdehyde, folate, and B12 levels were measured.Results: After folate supplementation in the folic acid group, homocysteine was significantly decreased (15.1 +/- 3.2 to 12.1 +/- 3.1 mu mol/L, p < 0.001) and folate and B12 levels were significantly increased (p < 0.001). A significant increase in total antioxidant capacity (0.96 +/- 0.2 to 1.14 +/- 0.3 mmol Fe2+/L, p < 0.001) and a significant decrease in malondialdehyde (2.6 +/- 0.7 to 1.7 +/- 0.2 mu mol/L, p < 0.001) were observed in the folic acid group, whereas no significant changes occurred in the placebo group (p > 0.05).Conclusion: Pharmacological doses of folate supplementation lowered plasma homocysteine and serum malondialdehyde levels and improved serum total antioxidant capacity and folate and B12 levels in patients with type 2 diabetes.