The EGF and FGF receptors mediate neuroglian function to control growth cone decisions during sensory axon guidance in Drosophila
The EGF and FGF receptors mediate neuroglian function to control growth cone decisions during sensory axon guidance in Drosophila
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DOI：
10.1016/s0896-6273(00)00150-1
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发表时间：
2000-12-01
期刊：
影响因子：
16.2
通讯作者：
Jiménez, F
中科院分区：
文献类型：
--
作者：
García-Alonso, L;Romani, S;Jiménez, F
Cell adhesion molecules (CAMs) implement the process of axon guidance by promoting specific selection and attachment to substrates. We show that, in Drosophila, loss-of-function conditions of either the Neuroglian CAM, the FGF receptor coded by the gene heartless, or the EGF receptor coded by DER display a similar phenotype of abnormal substrate selection and axon guidance by peripheral sensory neurons. Moreover, neuroglian loss-of-function phenotype can be suppressed by the expression of gain-of-function conditions of heartless or DER. The results are consistent with a scenario where the activity of these receptor tyrosine kinases is controlled by Neuroglian at choice points where sensory axons select between alternative substrates for extension.
