New direct evidence that histamine augments bladder sensory outflow during filling is nothing to sneeze at.
New direct evidence that histamine augments bladder sensory outflow during filling is nothing to sneeze at.
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新的直接证据表明组胺在充盈过程中会增加膀胱感觉流出，这是不容忽视的。
DOI：
10.1152/ajprenal.00581.2019
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Tykocki,NathanR
中科院分区：
文献类型：
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作者：
Jones,BMalique;Tykocki,NathanR
结论总之，格伦迪等人能够应用他们对组胺依赖性机制的知识，调节其他器官（如胃肠道）的机械感觉神经支配，阐明组胺可直接引起与IC/BPS相似的症状发作的合理和合乎逻辑的作用机制。这项工作确实建立了TRPV 1通道，组胺和组胺受体的中枢和外周作用之间的创新联系，通过改变膀胱充盈的感觉来诱导膀胱功能障碍。它还强调并进一步支持需要研究组胺能信号传导不仅仅是炎症驱动的肥大细胞脱粒的结果，而是膀胱功能障碍的潜在直接原因。
CONCLUSIONSIn summary, Grundy et al. were able to apply their knowledge of histamine-dependent mechanisms that regulate mechanosensory innervation in other organs (eg, the gastrointestinal tract) to elucidate a sound and logical mechanism of action by which histamine could directly cause the onset of symptoms similar to those seen in IC/BPS. This work has indeed established an innovative link between the central and peripheral roles of TRPV1 channels, histamine, and histamine receptors to induce bladder dysfunction through alterations in the sensation of bladder fullness. It also highlights and further supports the need to investigate histaminergic signaling as more than the result of inflammation-driven mast cell degranulation but as a potential direct cause of bladder dysfunction.