What has diffusion imaging in animals told us about diffusion imaging in patients with ischaemic stroke?
What has diffusion imaging in animals told us about diffusion imaging in patients with ischaemic stroke?
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DOI：
10.1159/000084691
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发表时间：
2005-01-01
影响因子：
2.9
通讯作者：
Wardlaw, JM
中科院分区：
文献类型：
--
作者：
Rivers, CS;Wardlaw, JM
背景和目的：在急性缺血性中风中，尚不清楚扩散体重成像（DWI）病变的细胞损伤的量（和类型）尚不清楚。我们总结了局灶性缺血模型中DWI实验研究的所有信息。方法：我们系统地回顾了局灶性缺血性中风模型中DWI的所有已发表研究。我们提取了关键的实验细节，以确定组织学特征和DWI病变特征之间的相关性。结果：在141篇可能合格的论文（包括2817种以上的动物，主要是大鼠）中，不幸的是，关键实验方法的细节经常被省略。在具有盲目分析的高质量研究中，一致的发现包括：尽管早期DWI病变“归一化”，神经元损伤仍然存在或进展；明显的扩散系数对神经元损伤的量不太敏感。 DWI病变的“更明亮”，神经元损害越大；与神经元的变化相比，DWI病变可能反映出神经胶质。麻醉和固定技术可能会无意中影响这些发现。结论：细胞损伤与DWI病变外观（尤其是再灌注实验中的恢复模式）之间的关系仍然不精确。关键的实验细节可以更全面地报告。需要解决重复麻醉的潜在问题。急性中风患者的早期DWI病变“恢复”可能在很大程度上反映了神经胶质而不是神经元的“恢复”。版权（C）2005 S. Karger AG，巴塞尔。
Background and Purpose: In acute ischaemic stroke, the amount (and type) of cellular damage underlying diffusionweighted imaging (DWI) lesion appearances is unclear. We summarized all information from experimental studies of DWI in focal ischaemia models. Methods: We systematically reviewed all published studies of DWI in focal ischaemic stroke models. We extracted key experimental details to determine correlations between histological features and DWI lesion characteristics. Results: Of 141 potentially eligible papers (including more than 2,817 animals, mostly rats), details of key experimental methods were unfortunately often omitted. Consistent findings amongst high-quality studies with blinded analysis included: neuronal damage persists or progresses despite early DWI lesion 'normalisation'; the apparent diffusion coefficient is not very sensitive to the amount of neuronal damage; the 'brighter' the DWI lesion, the greater the neuronal damage; and the DWI lesion may reflect glial more than neuronal changes. Anaesthesia and fixation techniques may inadvertently affect these findings. Conclusions: The relationship between cellular damage and DWI lesion appearance, particularly recovery patterns in reperfusion experiments, remains imprecise. Key experimental details could be reported more completely and consistently. Potential problems from repeated anaesthetics need to be addressed. Early DWI lesion 'recovery' in acute stroke patients may largely reflect glial rather than neuronal 'recovery'. Copyright (C) 2005 S. Karger AG, Basel.