Cortical sources of resting state EEG rhythms are abnormal in dyslexic children
Cortical sources of resting state EEG rhythms are abnormal in dyslexic children
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DOI：
10.1016/j.clinph.2012.05.002
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发表时间：
2012-12-01
影响因子：
4.7
通讯作者：
Rossini, Paolo M.
中科院分区：
文献类型：
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作者：
Babiloni, Claudio;Stella, Giacomo;Rossini, Paolo M.
目的：以前的研究一直没有定论，是否占主导地位的静息状态α节律的幅度不同，在睡眠障碍的主题相比，对照组，这些节奏被认为是有效的皮质神经同步和认知的反映。在这里，我们使用经验证的EEG源估计来测试睡眠障碍受试者的静息状态α节律异常并且与阅读缺陷相关的假设。本文记录了26例阅读障碍者的闭眼静息状态脑电图（EEG）（12名男性，平均年龄11岁+/-0.5平均值标准误差，SEM）和11名年龄匹配的正常对照受试者（8名男性，平均年龄11岁+/-0.7 SEM）。基于个体α频率峰值，感兴趣的EEG节律如下：约2-4 Hz（δ）、4-6 Hz（θ）、6-8 Hz（α 1）、8-10 Hz（α 2）和10-12 Hz（α 3）。对于较高的频率，我们选择beta 1（13-20 Hz），beta 2（20-30 Hz）和gamma（30-40 Hz）。皮质脑电来源估计低分辨率电磁断层扫描（LORETA）。LORETA解决方案在所有的体素和frequency.Results：正常对照组儿童相比，诵读困难表现出较低的振幅顶叶，枕叶，颞叶α 2和α 3源。在阅读障碍者中，这些来源中的一些与伪词的阅读时间相关（顶叶α 2，r =-0.56，p = 0.02;顶叶α 3，r =-0.58，p = 0.02;颞叶α 3，r =-0.57，p = 0.02）; α功率越高，阅读时间越短。阅读障碍儿童的特点是有限的异常静息态脑电节律的地形（后区）和频率（α），这与语音编码有关（伪词阅读）。意义：阅读障碍可能与静息状态下皮质神经元同步机制的某些功能障碍有关。(C)2012年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: Previous studies have been inconclusive whether dominant resting state alpha rhythms differ in amplitude in dyslexic subjects when compared to control subjects, being these rhythms considered as a reflection of effective cortical neural synchronization and cognition. Here we used a validated EEG source estimation to test the hypothesis that resting state alpha rhythms are abnormal in dyslexic subjects and are related to reading deficits.Methods: Eyes-closed resting state electroencephalographic (EEG) data were recorded in 26 dyslexics (12 males, mean age of 11 years +/- 0.5 standard error of mean, SEM) and 11 age-matched normal control subjects (8 males, mean age of 11 years +/- 0.7 SEM). EEG rhythms of interest, based on individual alpha frequency peak, were the following: about 2-4 Hz (delta), 4-6 Hz (theta), 6-8 Hz (alpha 1), 8-10 Hz (alpha 2), and 10-12 Hz (alpha 3). For the higher frequencies, we selected beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-40 Hz). Cortical EEG sources were estimated by low resolution electromagnetic tomography (LORETA). LORETA solutions were normalized across all voxels and frequencies.Results: Compared to the control children, the dyslexics showed lower amplitude of parietal, occipital, and temporal alpha 2 and alpha 3 sources. In the dyslexics, some of these sources were correlated to reading time of pseudo-words (parietal alpha 2, r = -0.56, p = 0.02; parietal alpha 3, r = -0.58, p = 0.02; temporal alpha 3, r = -0.57, p = 0.02); the higher the alpha power, the shorter the reading time.Conclusions: Dyslexic children are characterized by limited abnormalities of resting state EEG rhythms as to topography (posterior regions) and frequency (alpha), which were related to phonological encoding (pseudo-words reading).Significance: Dyslexia may be associated to some functional impairment of cortical neuronal synchronization mechanisms involved in the resting state condition. (C) 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.