Prophylactic doxycycline for travelers' diarrhea: Results of a prospective double-blind study of Peace Corps Volunteers in Morocco
Prophylactic doxycycline for travelers' diarrhea: Results of a prospective double-blind study of Peace Corps Volunteers in Morocco
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预防性使用强力霉素治疗旅行者腹泻：摩洛哥和平队志愿者的前瞻性双盲研究结果
DOI：
10.1016/0016-5085(79)90403-7
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发表时间：
1979
期刊：
影响因子：
29.4
通讯作者：
H. Greenberg
中科院分区：
文献类型：
--
作者：
R. Sack;J. Froehlich;A. W. Zulich;D. S. Hidi;A. Kapikian;F. Ørskov;I. Ørskov;H. Greenberg
在50名和平队志愿者在摩洛哥的头10周内，进行了第二项随机双盲研究，以确定每天100毫克的多西环素预防旅行者腹泻的疗效。志愿者服用多西环素或安慰剂3wk，并观察另外7wk。服用安慰剂的24人中有11人和服用多西环素的26人中有2人在治疗期间出现旅行者腹泻(P<；0.01)。然而，在多西环素停药一周后，该组患者出现旅行者腹泻的频率增加(P<；0.05)，因此在停药3周后，两组之间没有差异。在整个研究过程中，肠毒素产生性大肠杆菌是最常见的分离病原体，其中大多数对多西环素敏感。这项研究证实了强力霉素预防旅行者腹泻的有效性。
A second randomized double-blind study to determine the efficacy of doxycycline, 100 mg daily, for the prevention of travelers' diarrhea was carried out among 50 Peace Corps Volunteers during their first 10 wk in Morocco. The volunteers took either doxycycline or placebo for 3 wk, and were observed for an additional 7 wk. Eleven of 24 taking the placebo and 2 of 26 taking doxycycline had travelers' diarrhea during the treatment period (P < 0.01). One week after cessation of the doxycycline, however, persons in that group developed an increase in frequency of travelers' diarrhea (P < 0.05) so that by 3 wk after the drug was stopped, there were no differences between the groups. Enterotoxigenic E. coli, most of which were sensitive to doxycycline, were the most frequently isolated pathogens during the entire study. This study corroborates the effectiveness of doxycycline prophylaxis for travelers' diarrhea.