Serological evidence of rickettsial infections in Delhi
Serological evidence of rickettsial infections in Delhi
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德里立克次体感染的血清学证据
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
U. Rana
中科院分区：
文献类型：
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作者：
V. Mittal;N. Gupta;D. Bhattacharya;Kaushal Kumar;R. Ichhpujani;S. Singh;M. Chhabra;U. Rana
背景与目的：在发展中国家，由于缺乏诊断设施，立克次体感染仍被诊断不足。在这里，我们介绍了我们的经验，在国家疾病控制中心，德里，关于血清学调查在德里立克次体病易于执行低成本，低专业知识韦氏费利克斯测试。方法：以健康人群的临界滴度为基础，沿着临床资料对Weil Felix试验结果进行解释。还在德里的选定地区进行了昆虫学调查。从房屋和花园捕获啮齿动物，并收集病媒螨。结果如下：当在最初5年期间从不明原因发热患者中采集血清样本时，血清阳性率为8.2%，而当临床医生将立克次体感染作为鉴别诊断之一时，血清阳性率上升至33.3%，立克次体感染被检出为恙虫病2005-2009年，斑疹热组（27.5%）和斑疹伤寒组（6.8%）分别占48.2%和6.8%。在初步的昆虫学调查中，在啮齿动物身上发现了媒介螨Leptotombidium deliense。解释和结论：我们的研究结果表明，Weil Felix试验的结果不应被忽视，而应治疗临床相容的病例以挽救生命。
Background & objectives: Rickettsial infections remain under-diagnosed due to lack of diagnostic facilities in developing world. Here we present our experience at National Centre for Disease Control, Delhi, about a serosurvey done in Delhi for rickettsial disease with easy to perform low cost, low expertise Weil Felix test. Methods: On the basis of cut-off titre obtained in healthy population, Weil Felix test results were interpreted along with clinical data. Entomological investigation was also carried out in select areas of Delhi. Rodents were trapped from houses and gardens and vector mites were collected. Results: When serum samples were collected during initial 5 yr period from patients with fever of unknown origin, seropositivity was 8.2 per cent whereas when rickettsial infection was kept as one of the differential diagnosis by clinicians seropositivity increased to 33.3 per cent. Rickettsial infections detected were scrub typhus (48.2%) followed by spotted fever group (27.5%) and typhus group (6.8%) during 2005-2009. In preliminary entomological survey vector mite Leptotombidium deliense was found on rodents. Interpretation & conclusions: Our findings showed that results of Weil Felix test should not be disregarded, rather clinically compatible cases should be treated to save lives.