Comparison of transcatheter intraarterial perfusion MR imaging and fluorescent microsphere perfusion measurements during transcatheter arterial embolization of rabbit liver tumors
Comparison of transcatheter intraarterial perfusion MR imaging and fluorescent microsphere perfusion measurements during transcatheter arterial embolization of rabbit liver tumors
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DOI：
10.1016/j.jvir.2007.07.008
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发表时间：
2007-10-01
影响因子：
2.9
通讯作者：
Omary, Reed A.
中科院分区：
文献类型：
--
作者：
Virmani, Sumeet;Wang, Dingxin;Omary, Reed A.
目的：经导管动脉灌注（TRIP）磁共振（MR）成像在临床上用于介入性磁共振成像设置，以验证肝定向经导管治疗期间注射栓塞或化学栓塞物质的分布，并监测灌注减少。这种技术的准确性尚不清楚。本研究以兔VX2肝肿瘤为研究对象，以荧光微球注射为金标准技术，验证TRIP MR成像准确测量经导管动脉栓塞（transcatheter artery embolization， TAE）过程中肿瘤灌注变化的假设。材料与方法：5只新西兰大白兔（2只供兔，3只VX2肝肿瘤）。在3只植入VX2肝肿瘤的兔子中，在数字减影血管造影引导下，超选择性地将导管置入供应目标肿瘤的肝左动脉。荧光微球注射于TAE前后的每只兔的左心室。所有家兔动脉内注射2.5%加佐戊二胺二聚氰胺溶液，在基线和栓塞后获得TRIP MR图像。线性回归比较TRIP MR成像与荧光微球成像对肿瘤灌注的相对减少。当P值小于0.05时，认为结果具有统计学意义。结果：TRIP MR成像与荧光微球测量的肿瘤灌注减少有良好的相关性(r = 0.722， P
PURPOSE: Transcatheter intraarterial perfusion (TRIP) magnetic resonance (MR) imaging is clinically used in the interventional MR imaging setting to verify distribution of injected embolic or chemoembolic material during liver-directed transcatheter therapies and to monitor reductions in perfusion. The accuracy of this technique remains unknown. In the present study, rabbit VX2 liver tumors were used to test the hypothesis that TRIP MR imaging accurately measures changes in tumor perfusion during transcatheter arterial embolization (TAE), with injection of fluorescent microspheres used as the gold-standard technique.MATERIALS AND METHODS: Five New Zealand White rabbits were used for this study (two donor rabbits and three with VX2 liver tumors). In three rabbits with implanted VX2 liver tumors, catheters were superselectively placed under digital subtraction angiographic guidance into the left hepatic artery supplying the targeted tumor. Fluorescent microspheres were injected into each rabbit's left ventricle before and after TAE. TRIP MR images were obtained at baseline and after embolizations for all rabbits with intraarterial injections of 2.5% gadopentetate dimeglumine solution. Linear regression was used to compare relative reductions in tumor perfusion between TRIP MR imaging and fluorescent microspheres. Results were considered statistically significant at a P value less than .05.RESULTS: There was good correlation between TRIP MR imaging and fluorescent microsphere measurements of reduction in tumor perfusion (r = 0.722, P