Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex.
Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex.
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DOI：
10.1038/s41598-021-89379-x
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发表时间：
2021-05-07
影响因子：
4.6
通讯作者：
Pajvani UB
中科院分区：
文献类型：
--
作者：
Bartolomé A;Liang J;Wang P;Ho DD;Pajvani UB
Angiotensin converting enzyme 2 (ACE2) is a key regulator of the renin-angiotensin system, but also the functional receptor of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Based on structural similarity with other γ-secretase (γS) targets, we hypothesized that ACE2 may be affected by γS proteolytic activity. We found that after ectodomain shedding, ACE2 is targeted for intramembrane proteolysis by γS, releasing a soluble ACE2 C-terminal fragment. Consistently, chemical or genetic inhibition of γS results in the accumulation of a membrane-bound fragment of ectodomain-deficient ACE2. Although chemical inhibition of γS does not alter SARS-CoV-2 cell entry, these data point to a novel pathway for cellular ACE2 trafficking.
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影响因子：
5.4
作者：
Heurich, Adeline;Hofmann-Winkler, Heike;Poehlmann, Stefan
通讯作者：
Poehlmann, Stefan
影响因子：
64.8
作者：
Li W;Moore MJ;Vasilieva N;Sui J;Wong SK;Berne MA;Somasundaran M;Sullivan JL;Luzuriaga K;Greenough TC;Choe H;Farzan M
通讯作者：
Farzan M
影响因子：
15.9
作者：
Bartolome, Alberto;Zhu, Changyu;Pajvani, Utpal B.
通讯作者：
Pajvani, Utpal B.
DOI：
10.1534/g3.118.200144
发表时间：
2018-07-02
期刊：
G3 (Bethesda, Md.)
影响因子：
--
作者：
Edie S;Zaghloul NA;Leitch CC;Klinedinst DK;Lebron J;Thole JF;McCallion AS;Katsanis N;Reeves RH
通讯作者：
Reeves RH
影响因子：
5.4
作者：
Glowacka, Ilona;Bertram, Stephanie;Poehlmann, Stefan
通讯作者：
Poehlmann, Stefan