Iron-Catalyzed Allylic Amination Directly from Allylic Alcohols
Iron-Catalyzed Allylic Amination Directly from Allylic Alcohols
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DOI：
10.1002/chem.201505214
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发表时间：
2016-03-14
影响因子：
4.3
通讯作者：
Sundararaju, Basker
中科院分区：
文献类型：
--
作者：
Emayavaramban, Balakumar;Roy, Moumita;Sundararaju, Basker
使用高效且区域特异性的分子铁催化剂，已证明直接从醇中进行烯丙位胺化，无需任何刘易斯酸活化剂。采用各种胺和醇，并且反应通过氧化/还原（氧化还原）途径进行。以肉桂醇为原料，一步合成了桂利嗪、萘替芬等常用药物，副产物为水。
Allylic amination, directly from alcohols, has been demonstrated without any Lewis acid activators using an efficient and regiospecific molecular iron catalyst. Various amines and alcohols were employed and the reaction proceeded through the oxidation/reduction (redox) pathway. A direct one-step synthesis of common drugs, such as cinnarizine and nafetifine, was exhibited from cinnamyl alcohol that produced water as side product.