Novel cycloSal nucleotides with reduced inhibitory potency toward human butyrylcholinesterase
Novel cycloSal nucleotides with reduced inhibitory potency toward human butyrylcholinesterase
复制标题
DOI：
10.1081/ncn-200061791
复制
发表时间：
2005-01-01
影响因子：
1.3
通讯作者：
Meier, C
中科院分区：
文献类型：
--
作者：
Ducho, C;Jessel, S;Meier, C
通过一条新的合成路线合成了两种新型的具有更高空间需求量的环醛-d4T单磷酸酯(D4TMPs)。而3-环己基-环醛-d4TMP对人丁基胆碱酯酶的抑制作用没有明显降低，而第二个新的原核苷酸bi-(环醛-d4TMP)则相反。
Two novel cycloSal-d4T monophosphates (d4TMPs) with increased steric demand have been synthesized via a new synthetic route. While 3-cyclohexyl-cycloSal d4TMP did not show a significantly reduced inhibitory potency toward human butrylylcholinesterase, the opposite was the case for the second novel pronucleotide, bi-(cycloSal-d4TMP).