Is freezing of gait in Parkinson's disease related to asymmetric motor function?
Is freezing of gait in Parkinson's disease related to asymmetric motor function?
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DOI：
10.1002/ana.20452
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发表时间：
2005-05-01
影响因子：
11.2
通讯作者：
Hausdorff, JM
中科院分区：
文献类型：
--
作者：
Plotnik, M;Giladi, N;Hausdorff, JM
冻结步态 (FOG) 是晚期帕金森病 (PD) 患者常见的一种致残现象。 FOG 的原因尚不清楚。本研究的目的是探索一个新的假设，指出 FOG 与不对称运动表现有关。我们将经历过 FOG 发作 (PD+FOG) 的 PD 患者与未经历过 FOG 发作的 PD 患者 (PD-FOG) 进行比较，并研究了 FOG 与步态和节律性手部运动表现不对称的关系，以确定潜在的 FOG 相关步态不对称是否是行走所特有的，还是全身性的。受试者在“关闭”（未用药）状态下进行测试，并在“开启”（用药）状态下再次进行测试。在“关闭”状态 (p = 0.005) 和“开启”状态 (p = 0.016) 期间，PD+FOG 的步态比 PD-FOG 的步态更不对称。在 PD-FOG 中，一条腿的足部摆动节奏与另一条腿相关，但在 PD+FOG 中则不然。两组之间有节奏的手部动作表现的不对称性没有差异。临床症状不对称与步态不对称之间没有发现相关性。总而言之，这项研究的结果表明，双侧步态不协调和明显的步态不对称，但一般运动表现的不对称，与 FOG 相关。
Freezing of gait (FOG) is a disabling phenomenon common in patients with advanced Parkinson's disease (PD). The cause of FOG is unclear. The objective of this study was to explore a novel hypothesis stating that FOG is related to asymmetric motor performance. We compared PD patients that experience FOG episodes (PD+FOG) with PD patients that do not (PD-FOG) and studied the relationship of FOG to asymmetry in gait and in rhythmic hand movement performance to determine whether potential FOG-related gait asymmetry is unique to walking or whether it is systemic. Subjects were tested in an "off" (unmedicated) and again in an "on" (medicated) state. Gait was more asymmetric in PD+FOG than in PD-FOG during "off" state (p = 0.005) and during "on" (p = 0.016). Rhythmicity of foot swing in one leg was correlated with the other leg in PD-FOG but not in PD+FOG. There was no difference in asymmetry in performance of rhythmic hand movements between the two groups. No correlation was found between asymmetry of clinical symptoms and gait asymmetry. Taken together, the results of this study suggest that bilateral uncoordinated gait and marked gait asymmetry, but not asymmetry in motor performance in general, are associated with FOG.