The Glasgow prognostic score divides high-risk hematopoietic cell transplantation-specific comorbidity index patients into stratified subgroups in allogeneic hematopoietic cell transplantation
The Glasgow prognostic score divides high-risk hematopoietic cell transplantation-specific comorbidity index patients into stratified subgroups in allogeneic hematopoietic cell transplantation
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格拉斯哥预后评分将高危造血细胞移植特异性合并症指数患者分为同种异体造血细胞移植中的分层亚组
DOI：
10.1007/s00277-020-03936-4
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发表时间：
2020
影响因子：
3.5
通讯作者：
Masuko Masayoshi
中科院分区：
文献类型：
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作者：
Shibasaki Yasuhiko;Suwabe Tatsuya;Katagiri Takayuki;Fuse Kyoko;Narita Miwako;Sone Hirohito;Masuko Masayoshi
虽然异基因造血细胞移植（allo-HCT）具有治愈血液病患者的潜力，但它存在非复发死亡率（NRM）的风险。造血细胞移植特异性合并症指数（HCTCI）是一种确定allo-HCT前移植前风险分层的既定指标[1]。由于NRM的发生率较高，因此归类为高风险HCT-CI组的患者需要仔细考虑allo-HCT。因此，使用其他因素对高风险HCT-CI组进行进一步分层可能有助于确定allo-HCT设置。据报道，与炎症和营养状态相关的几种生物标志物，如血清铁蛋白（SF）、白蛋白（Alb）和C反应蛋白（CRP）与allo-HCT的预后相关[2-5]。其中，基于CRP和Alb值的格拉斯哥预后评分（GPS）[6]是预测allo-HCT预后的有用工具，独立于HCT-CI [7，8]。在本研究中，我们成功地将高风险
Dear Editor, Although allogeneic hematopoietic cell transplantation (allo-HCT) has the potential to cure patients with hematological disease, it carries risks of non-relapse mortality (NRM). The hematopoietic cell transplantation-specific comorbidity index (HCTCI) is an established index for determining pre-transplant risk stratification before allo-HCT [1]. Because of the high rate of NRM, patients categorized into the high-risk HCT-CI group require careful consideration regarding allo-HCT. Therefore, further stratification of the high-risk HCT-CI group using other factors may be useful to determine the allo-HCT setting. Several biomarkers related to inflammatory and nutritional status, such as serum ferritin (SF), albumin (Alb), and C-reactive protein (CRP), have been reported to be correlated with the prognosis of allo-HCT [2–5]. Among them, the Glasgow prognostic score (GPS), which based on the values of the CRP and Alb [6], is a useful tool for the prediction of prognosis with allo-HCT independent to the HCT-CI [7, 8]. In the present study, we succeeded in dividing the high-risk