Affect-Related Brain Activity and Adolescent Substance Use: A Systematic Review.
Affect-Related Brain Activity and Adolescent Substance Use: A Systematic Review.
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与影响相关的大脑活动和青少年物质使用：系统评价。
DOI：
10.1007/s40473-021-00241-w
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发表时间：
2022-03
影响因子：
1.7
通讯作者：
Chaplin, Tara M
中科院分区：
文献类型：
--
作者：
Goncalves, Stefanie F;Ryan, Mary;Niehaus, Claire E;Chaplin, Tara M
本综述旨在总结情感处理（即奖励、负面情绪刺激、丧失）和青少年物质使用（SU）过程中大脑活动的研究。大多数研究揭示了中扣带岛、额顶叶和其他网络区域的神经活动改变与青少年 SU 之间的联系。中扣带岛区（尤其是纹状体）对积极情感刺激（例如金钱奖励）的募集增加通常与物质的起始和低水平使用有关，而这些区域募集的减少通常与 SUD 和高风险 SU 相关。关于负面情感刺激，大多数研究表明中扣带岛网络区域的招募增加。还有证据表明这些关联可能具有性别特异性。未来的研究应该采用纵向设计来评估 SU 启动和升级之前和之后与情感相关的大脑活动。此外，将性别作为调节变量进行检查可能有助于澄清情感神经危险因素是否具有性别特异性。
This review aims to summarize the research on brain activity during affective processing (i.e., reward, negative emotional stimuli, loss) and adolescent substance use (SU). Most research revealed links between altered neural activity in midcingulo-insular, frontoparietal and other network regions and adolescent SU. Increased recruitment of midcingulo-insular regions—particularly the striatum—to positive affective stimuli (e.g., monetary reward) was most often associated with initiation and low-level use of substances, whereas decreased recruitment of these regions was most often associated with SUD and higher risk SU. In regards to negative affective stimuli, most research demonstrated increased recruitment of midcingulo-insular network regions. There is also evidence that these associations may be sex-specific. Future research should employ longitudinal designs that assess affect-related brain activity prior to and following SU initiation and escalation. Moreover, examining sex as as moderating variable may help clarify if affective neural risk factors are sex-specific.