Circulating hyaluronan in the myelofibrosis/osteomyelosclerosis syndrome and other myeloproliferative disorders
Circulating hyaluronan in the myelofibrosis/osteomyelosclerosis syndrome and other myeloproliferative disorders
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骨髓纤维化/骨髓硬化综合征和其他骨髓增殖性疾病中的循环透明质酸
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
A. Laurent
中科院分区：
文献类型：
--
作者：
H. Hasselbalch;P. Junker;I. Lisse;U. Lindqvist;A. Laurent
本文测定了59例骨髓增生性疾病（包括33例特发性骨髓纤维化）患者血清透明质酸（HYA）浓度。在18例患者的血清浓度的氨基末端前肽的III型前胶原（PIIINP）进行了测定伴随。与年龄匹配的健康受试者相比，在活动性疾病患者中观察到血清HYA水平升高，而在稳定性疾病患者和年龄匹配的对照组之间观察到血清HYA无显著差异。血清HYA浓度与白细胞计数（rho = 0.38; P < 0.02）和血清PIIINP浓度（rho = 0.50; P < 0.001）显著相关。在细胞毒性治疗期间，血清HYA和PIIINP浓度随着白细胞计数的下降而下降。这些发现表明，克隆扩张伴随着骨髓基质反应，类似于软结缔组织损伤后的修复过程。血清HYA的相对适度的变化与患者类别和健康受试者之间的频繁重叠意味着在本疾病组中血清HYA的单一测定的临床效用受到限制。另一方面，连续测量HYA可以反映个体患者的骨髓增生过程。
The serum concentration of hyaluronan (HYA) was determined in 59 patients with various myeloproliferative disorders, including 33 patients with idiopathic myelofibrosis. In 18 patients the serum concentration of the aminoterminal propeptide of type III procollagen (PIIINP) was measured concomitantly. Raised serum HYA levels were seen in patients with active disease compared with age‐matched healthy subjects, whereas no significant difference in serum HYA was seen between patients with stable disease and age‐matched controls. Serum HYA concentrations correlated significantly with the leukocyte count (rho = 0.38; P < 0.02) and with the serum concentration of PIIINP (rho = 0.50; P < 0.001). During cytotoxic treatment, the serum HYA and PIIINP concentrations decreased in concert with declining leukocyte counts. These findings suggest that clonal expansion is accompanied by a bone marrow stromal reaction similar to the repair processes following injury to soft connective tissues. The relatively modest changes in serum HYA with frequent overlaps between patient categories and healthy subjects imply that the clinical utility of single determinations of serum HYA in the present disease groups is restrained. On the other hand, sequential measurements of HYA may provide a reflection of the myeloproliferative process in individual patients.
影响因子：
20.3
作者：
Minguell,JJ;Tavassoli,M
通讯作者：
Tavassoli,M
人中性粒细胞和白血病成髓细胞中的糖胺聚糖：超微结构、细胞化学、免疫学和生化特征。
影响因子：
20.3
作者：
Parmley,RT;Hurst,RE;Takagi,M;Spicer,SS;Austin,RL
通讯作者：
Austin,RL