Test anxiety and telomere length: Academic stress in adolescents may not cause rapid telomere erosion.
Test anxiety and telomere length: Academic stress in adolescents may not cause rapid telomere erosion.
复制标题
考试焦虑和端粒长度：青少年的学业压力可能不会导致端粒快速侵蚀
DOI：
10.18632/oncotarget.14793
复制
发表时间：
2017-02-14
期刊：
影响因子：
--
通讯作者：
Lu Y
中科院分区：
文献类型：
--
作者：
Zou Y;Leong W;Yao M;Hu X;Lu S;Zhu X;Chen L;Tong J;Shi J;Gilson E;Ye J;Lu Y
学业压力（AS）是学生经历的最重要的健康问题之一，但尚未确定与AS相关的潜在心理或生理问题的生物标志物。由于几项横断面研究表明精神疾病会加速衰老并缩短端粒长度（TL），因此我们探讨了AS是否影响TL。2014年6月至2014年7月，我们招募了200名即将参加期末考试的初中生参与本研究。学生被分为三个亚组（轻度，中度和严重焦虑）使用Sarason考试焦虑量表（TAS）。收集唾液样本，通过定量聚合酶链反应（qPCR）进行TL测量。中专生和普通高中生的焦虑水平差异无统计学意义（p > 0.05）。35%的患者有重度焦虑（得分：26.093.87），33%的患者有中度焦虑（得分：16.982.64），32%的患者有轻度焦虑（得分：7.891.92）。三个亚组的TAS值差异显著（p < 0.05），但唾液细胞的TL值仅略有差异（p > 0.05）：重度焦虑组为1.14 ± 0.46，中度焦虑组为1.02 ± 0.40，轻度焦虑组为1.12 ± 0.45。以往的报道发现，AS在亚洲青少年中非常常见。我们没有发现AS青少年的端粒立即缩短。需要进行纵向观察以确定TL是否受AS影响。
Academic stress (AS) is one of the most important health problems experienced by students, but no biomarker of the potential psychological or physical problems associated with AS has yet been identified. As several cross-sectional studies have shown that psychiatric conditions accelerate aging and shorten telomere length (TL), we explored whether AS affected TL. Between June 2014 and July 2014, we recruited 200 junior high school students with imminent final examinations for participation in this study. The students were divided into three subgroups (mild, moderate, and severe anxiety) using the Sarason Test Anxiety Scale (TAS). Saliva samples were collected for TL measurement via quantitative polymerase chain reaction (qPCR). Students from both a specialized and a general school suffered from anxiety (p > 0.05). A total 35% had severe anxiety (score: 26.093.87), 33% had moderate anxiety (16.982.64), and 32% had mild anxiety (7.891.92). The TAS values differed significantly (p < 0.05) among the three subgroups, but the TLs of saliva cells differed only slightly (p > 0.05): 1.140.46 for those with severe anxiety, 1.020.40 for those with moderate anxiety, and 1.120.45 for those with mild anxiety. Previous reports have found that AS is very common in Asian adolescents. We found no immediate telomere shortening in adolescents with AS. Longitudinal observations are required to determine if TL is affected by AS.