SYSTERS, GeneNest, SpliceNest: exploring sequence space from genome to protein
SYSTERS, GeneNest, SpliceNest: exploring sequence space from genome to protein
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DOI：
10.1093/nar/30.1.299
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发表时间：
2002-01-01
影响因子：
14.9
通讯作者：
Vingron, M
中科院分区：
文献类型：
--
作者：
Krause, A;Haas, SA;Vingron, M
我们将 SYSTERS 中的蛋白质家族和我们数据库 GeneNest 中的表达序列标签 (EST) 簇集成到 SpliceNest 中，SpliceNest 是一个将 EST 重叠群映射到基因组 DNA 的新数据库。 SYSTERS 蛋白质序列簇集可自动将 SWISS-PROT、TrEMBL 和 PIR 数据库的所有序列分类为不相交的蛋白质家族和超家族簇。 GeneNest 是一个数据库和软件包，用于从 EST 和 mRNA 生成和可视化基因索引。目前，该数据库包含人类、小鼠、拟南芥和斑马鱼的基因索引。 SpliceNest 是一种基于网络的图形工具，用于探索基因结构，包括选择性剪接，基于从 GeneNest 到完整人类基因组的 EST 共有序列的映射。将 SYSTERS、GeneNest 和 SpliceNest 集成到一个框架中，现在可以全面探索涵盖蛋白质、mRNA 和 EST 序列以及基因组 DNA 的整个序列空间。数据库可在http://cmb.molgen.mpg.de 查询和浏览。
We have integrated the protein families from SYSTERS and the expressed sequence tag (EST) clusters from our database GeneNest with SpliceNest, a new database mapping EST contigs into genomic DNA. The SYSTERS protein sequence cluster set provides an automatically generated classification of all sequences of the SWISS-PROT, TrEMBL and PIR databases into disjoint protein family and superfamily clusters. GeneNest is a database and software package for producing and visualizing gene indices from ESTs and mRNAs. Currently, the database comprises gene indices of human, mouse, Arabidopsis thaliana and zebrafish. SpliceNest is a web-based graphical tool to explore gene structure, including alternative splicing, based on a mapping of the EST consensus sequences from GeneNest to the complete human genome. The integration of SYSTERS, GeneNest and SpliceNest into one framework now permits an overall exploration of the whole sequence space covering protein, mRNA and EST sequences, as well as genomic DNA. The databases are available for querying and browsing at http://cmb.molgen.mpg.de.