Vitamin D and calcium dyshomoeostasis-associated heart failure
Vitamin D and calcium dyshomoeostasis-associated heart failure
复制标题
维生素 D 和钙动态平衡失调相关的心力衰竭
作者：
K. Weber;R. Simpson;L. Carbone
心脏通常是一个有效的生理泵，其肌肉间隔由由冠状血管滋养的心肌细胞合胞体组成，并位于结构蛋白的支架内。心肌细胞的收缩特性是由Ca~(2+)与收缩蛋白、肌动蛋白和肌球蛋白的直接相互作用以及它们在细胞内对Ca~(2+)的处理决定的。同样，细胞外钙离子处理，或钙离子稳态，可以间接影响心肌细胞的收缩能力。在这里，我们简要地研究了钙离子代谢紊乱和心力衰竭。
血浆Ca~(2+)浓度被高度调节并维持在一个狭窄的范围内。如果受到干扰，一系列控制因素和反馈机制就会发挥作用。总体而言，钙稳态与其饮食摄入量、肠道和肾脏的吸收和排泄、骨骼储存以及骨钙素(活性维生素D)和甲状旁腺激素(PTH)等促降钙素的调节作用有关。
在子宫内，胎儿生长和发育(包括骨骼)中钙离子的可获得性取决于孕妇因素，如：(A)膳食钙摄入量可能减少，特别是纯素食者或一些乳糖不耐受妇女，她们不吃奶制品；(B)尿和粪便中钙离子损失；(C)如果钙离子可获得性受到影响，可能会动员骨骼储存的钙离子；(D)通过血清25-羟基维生素D(25-(OH)D)水平来评估维生素D状况。25-(OH)D的水平主要取决于补充剂和阳光暴露，这可能会受到文化上强加的着装要求、皮肤色素沉着的限制，其中黑色素是一种天然防晒剂，要求更长时间暴露在阳光的紫外线成分中以产生维生素D，衰老的皮肤不太能产生维生素D，脂肪细胞将其隔离的肥胖症，…的海拔、纬度和地点(城市与农村)
The heart normally is an efficient physiological pump whose muscular compartment is composed of a syncytium of cardiomyocytes nourished by a coronary vasculature and housed within a scaffolding of structural proteins. The contractile properties of cardiomyocytes are governed by the direct interplay between Ca2+ and contractile proteins, actin and myosin, and their intracellular handling of Ca2+. Likewise, extracellular Ca2+ handling, or Ca2+ homoeostasis, can indirectly influence cardiomyocyte contractility. Herein, we briefly examine Ca2+ dyshomoeostasis and heart failure.
Plasma Ca2+ concentrations are highly regulated and maintained within a narrow range. If disturbed, a series of controlling factors and feedback mechanisms are called into play. Overall Ca2+ homoeostasis relates to its dietary intake; absorption and excretion from gut and kidneys; bone storage; and the modifying influence of such calcitropic hormones as calcitriol (activated vitamin D) and parathyroid hormone (PTH).
In utero, the availability of Ca2+ for fetal growth and development, including the bony skeleton, depends on maternal factors such as: ( a ) dietary Ca2+ intake, which may be reduced, particularly in vegans or in some women with lactose intolerance, who avoid dairy products; ( b ) urinary and fecal Ca2+ losses; ( c ) Ca2+ bone stores that may be mobilised if Ca2+ availability is compromised; and ( d ) vitamin D status, as assessed by serum 25-hydroxyvitamin D (25-(OH)D) levels. 25-(OH)D levels are chiefly dependent on supplementation and sunlight exposure that may be limited by culturally imposed dress code, skin pigmentation, where melanin is a natural sunscreen that mandates longer exposure to the UVB component of sunlight to generate vitamin D, senescent skin less able to produce vitamin D, obesity where adipocytes sequester it, the altitude, latitude and locale (urban vs rural) of …
白介素 6 在甲状旁腺激素诱导的体内骨吸收中的作用。
DOI：
10.1210/endo.140.10.7036
发表时间：
1999
期刊：
Endocrinology.
影响因子：
--
作者：
Grey,A;Mitnick,MA;Masiukiewicz,U;Sun,BH;Rudikoff,S;Jilka,RL;Manolagas,SC;Insogna,K
通讯作者：
Insogna,K
甲状旁腺激素介导其对尿毒症器官功能有害影响的机制。
影响因子：
3.3
作者：
Massry,SG;Smogorzewski,M
通讯作者：
Smogorzewski,M