The effects of hippocampectomy and of fimbria section upon the partial reinforcement extinction effect in rats
The effects of hippocampectomy and of fimbria section upon the partial reinforcement extinction effect in rats
复制标题
海马切除和海马伞切断对大鼠部分强化消退效应的影响
DOI：
10.1007/bf00236646
复制
发表时间：
1980
影响因子：
2
通讯作者：
J. Gray
中科院分区：
文献类型：
--
作者：
J. Rawlins;J. Feldon,;J. Gray
概述训练大鼠在小巷中奔跑，以获得每次试验（连续强化，CR）或随机50%的试验（部分强化，PR）给予的食物奖励，然后熄灭。假手术对照显示出通常的部分强化消退效应（PREE），即，PR训练的动物比CR训练的动物更能抵抗灭绝。PREE被取消的小脑切除术，这增加了CR训练的大鼠和PR训练的大鼠的灭绝阻力。双侧海马伞部分在任何条件下对灭绝的抵抗力都没有影响。这些结果进行了讨论，根据海马功能的理论和隔海马连接的解剖。
SummaryRats were trained to run in an alley for food reward given on every trial (continuous reinforcement, CR) or on a random 50% of trials (partial reinforcement, PR) and were then extinguished. Sham-operated controls showed the usual partial reinforcement extinction effect (PREE), i.e., PR-trained animals were more resistant to extinction than CR-trained animals. The PREE was abolished by hippocampectomy, which increased resistance to extinction in CR-trained rats and decreased it in PR-trained rats. Bilateral fimbria section had no effect on resistance to extinction in either condition. These results are discussed in the light of theories of hippocampal function and the anatomy of septohippocampal connections.