Slow EEG Amplitude Oscillations During NREM Sleep and Reading Disabilities in Children With Dyslexia
Slow EEG Amplitude Oscillations During NREM Sleep and Reading Disabilities in Children With Dyslexia
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DOI：
10.1080/87565640903133418
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发表时间：
2009-01-01
影响因子：
1.5
通讯作者：
Curatolo, Paolo
中科院分区：
文献类型：
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作者：
Bruni, Oliviero;Ferri, Raffaele;Curatolo, Paolo
研究目的：采用循环交替模式（CAP）分析方法，分析阅读障碍儿童的非快速眼动（NREM）睡眠微结构，并将CAP参数与神经心理学指标相关联。设计：采用多导睡眠图记录和神经心理学评估的横断面研究。单位：学术中心睡眠实验室。参会人员：16名发育性阅读障碍儿童（平均年龄10.8岁）和11名正常阅读儿童（平均年龄10.1岁）接受了整夜多导睡眠图记录。干预：不适用。测量和结果：睡眠结构参数仅显示出一些统计学显著性差异：与对照组相比，睡眠障碍儿童每小时睡眠的睡眠阶段变化数、N3百分比和R期数显著降低。CAP分析显示N3期总CAP率和A1指数较高。N2和N3期的A2%和A2指数在睡眠障碍儿童中较低，而A3 CAP亚型之间无差异。CAP各参数与认知行为指标的相关分析显示，N3的A1指数与言语智商、全量表智商、记忆和学习迁移阅读测验呈显著正相关，N3的CAP率与言语智商呈显著正相关。结论：为了克服阅读困难，有阅读障碍的人会过度激活丘脑皮质和海马回路，在皮质的后部和前部区域之间传递信息。辅助额区的过度激活可以解释CAP率的变化，主要是CAP率和N3的A1指数的增加，这似乎与智商和阅读能力有关。
Study Objectives: To analyze non-rapid eye movement (NREM) sleep microstructure of children with dyslexia, by means of cyclic alternating pattern (CAP) analysis and to correlate CAP parameters with neuropsychological measures. Design: Cross-sectional study using polysomnographic recordings and neuropsychological assessments. Setting: Sleep laboratory in academic center. Participants: Sixteen subjects with developmental dyslexia (mean age 10.8 years) and 11 normally reading children (mean age 10.1 years) underwent overnight polysomnographic recording. Intervention: N/A. Measurements and Results: Sleep architecture parameters only showed some statistically significant differences: number of sleep stage shifts per hour of sleep, percentage of N3, and number of R periods were significantly lower in dyslexic children versus controls. CAP analysis revealed a higher total CAP rate and A1 index in stage N3. A2% and A2 index in stage N2 and N3 were lower in dyslexic children while no differences were found for A3 CAP subtypes. The correlation analysis between CAP parameters and cognitive-behavioral measures showed a significant positive correlation between A1 index in N3 with Verbal IQ, full-scale IQ, and Memory and Learning Transfer reading test; while CAP rate in N3 was positively correlated with verbal IQ. Conclusions: To overcome reading difficulties, dyslexic subjects overactivate thalamocortical and hippocampal circuitry to transfer information between cortical posterior and anterior areas. The overactivation of the ancillary frontal areas could account for the CAP rate modifications and mainly for the increase of CAP rate and of A1 index in N3 that seem to be correlated with IQ and reading abilities.