The hallmarks of cancer metabolism: Still emerging.
The hallmarks of cancer metabolism: Still emerging.
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DOI：
10.1016/j.cmet.2022.01.007
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发表时间：
2022-03-01
期刊：
影响因子：
29
通讯作者：
Thompson CB
中科院分区：
文献类型：
--
作者：
Pavlova NN;Zhu J;Thompson CB
癌细胞的代谢与生物质的产生和增殖有关。由于局部组织内的代谢资源是有限的，这可能导致营养耗尽和代谢废物的积累。为了在这些条件下维持生长，癌细胞采用多种代谢适应，其性质由其细胞来源的生理学、转化病变的身份和癌细胞所在的组织共同决定。此外，选择的代谢物不仅作为能量和生物质产生的底物，而且还可以调节基因和蛋白质表达，并影响肿瘤附近非转化细胞的行为。随着它们的生长和转移，肿瘤也会影响体内的营养分布并受到其影响。在这个标志更新中，最新的进展被纳入了一个概念框架，可能有助于指导进一步的研究工作，探索癌细胞代谢。Pavlova等人回顾了癌细胞代谢的最新发现和新范例。新的标志，包括肿瘤代谢多样性，电子受体和氧化应激保护的作用，以及肿瘤和全身代谢之间的串扰，被添加到癌细胞可以表现出的代谢标志列表中。
Metabolism of cancer cells is geared towards biomass production and proliferation. Since the metabolic resources within the local tissue are finite, this can lead to nutrient depletion and accumulation of metabolic waste. To maintain growth in these conditions, cancer cells employ a variety of metabolic adaptations, the nature of which is collectively determined by the physiology of their cell-of-origin, the identity of transforming lesions and the tissue in which cancer cells reside. Furthermore, select metabolites not only serve as substrates for energy and biomass generation, but can also regulate gene and protein expression and influence the behavior of non-transformed cells in the tumor vicinity. As they grow and metastasize, tumors can also affect and be affected by the nutrient distribution within the body. In this hallmarks update, recent advances are incorporated into a conceptual framework that may help guide further research efforts in exploring cancer cell metabolism. Pavlova et al. review the recent discoveries and emerging paradigms in cancer cell metabolism. New hallmarks, including the tumor metabolic diversity, the role of electron acceptors and oxidative stress protection, and the cross-talk between the tumor and whole-body metabolism are added to list of metabolic hallmarks cancer cells can exhibit.
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