Synthesis of Functionalized gem-Difluoroalkenes via a Photocatalytic Decarboxylative/Defluorinative Reaction.
Synthesis of Functionalized gem-Difluoroalkenes via a Photocatalytic Decarboxylative/Defluorinative Reaction.
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DOI：
10.1021/acs.joc.6b01620
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发表时间：
2016-08
期刊：
影响因子：
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通讯作者：
Tiebo Xiao;Linyong Li;Lei Zhou
中科院分区：
文献类型：
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作者：
Tiebo Xiao;Linyong Li;Lei Zhou
研究了α-三氟甲基烯烃与α-酮酸和α-氨基酸的光催化脱羧/脱氟反应。该反应在室温下可见光照射下进行，产率高，可得到多种γ，γ-二氟烯丙基酮和1,1-二氟均烯丙胺。还介绍了所制得的官能化宝石二氟烯烃的合成应用。
A photocatalytic decarboxylative/defluorinative reaction of α-trifluoromethyl alkenes with α-keto acids and α-amino acids has been developed. The reaction occurs at room temperature under visible light irradiation, affording various γ,γ-difluoroallylic ketones and 1,1-difluorohomoallyl amines in good yields. The synthetic applications of the resulting functionalized gem-difluoroalkenes were also described.