Cardiac autonomic profile in rheumatoid arthritis and systemic lupus erythematosus
Cardiac autonomic profile in rheumatoid arthritis and systemic lupus erythematosus
复制标题
DOI：
10.1177/0961203309351540
复制
发表时间：
2010-03-01
期刊：
影响因子：
2.6
通讯作者：
Terzioglu, E.
中科院分区：
文献类型：
--
作者：
Aydemir, M.;Yazisiz, V.;Terzioglu, E.
神经系统受累是系统性红斑狼疮（SLE）和类风湿性关节炎（RA）患者的一个有充分证据的问题。然而，对自主神经系统的参与知之甚少。本研究旨在探讨风湿性关节炎和SLE患者的自主神经系统功能障碍。从我们的门诊部招募了26名RA患者、38名SLE患者和40名健康对照者。心率变异性（HRV）参数（血流动力学时间序列的高[HF]和低频[LF]波段的功率，低频和高频分量之间的比率[LF/HF比值]，功率谱密度），气压反射灵敏度（BRS）和搏动血压通过一种新型的无创血流动力学监测工具（Task Force Monitor (R) [TFM], CNSystems Medizintechnik GmbH, Graz, Austria）进行评估。根据经典的尤因自主神经测试电池确定自主神经系统功能障碍。此外，我们通过使用附加标准修改Ewing测试组实现了二级自主测试分数。经典的和改良的Ewing测试电池都显示，与对照组相比，患者组自主神经病变的频率明显更高
Neurological involvement is a well-documented issue in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). However, little is known about the involvement of the autonomic nervous system. This study was conducted to investigate autonomic nervous system dysfunction in patients with RA and SLE. Twenty-six RA patients, 38 SLE patients and 40 healthy controls were recruited from our in-and out-patient departments. Heart rate variability (HRV) parameters (the power of the high-[HF] and low-frequency [LF] band of haemodynamic time series, the ratio between low-and high-frequency components [LF/HF ratio], the power spectral density), baroreflex sensitivity (BRS) and beat-to-beat blood pressures were assessed by a novel non-invasive haemodynamic monitoring tool (Task Force Monitor (R) [TFM], CNSystems Medizintechnik GmbH, Graz, Austria). Autonomic nervous system dysfunction was determined according to classical Ewing autonomic test battery. Furthermore, we implemented a secondary autonomic test score by modifying the Ewing test battery with additional criteria. Both the classical and modified Ewing test batteries have revealed that the frequencies of autonomic neuropathy were significantly higher in patient groups compared with controls (p