The dominance of inhibition in the inferior colliculus.
The dominance of inhibition in the inferior colliculus.
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DOI：
10.1016/j.heares.2010.05.010
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发表时间：
2011-04
期刊：
影响因子：
2.8
通讯作者：
Li N
中科院分区：
文献类型：
--
作者：
Pollak GD;Xie R;Gittelman JX;Andoni S;Li N
几乎所有的处理，发生在各种较低的听觉核集中在一个共同的目标，在中央核的下丘（ICc），从而使ICc的听觉系统的联系。各种新的响应特性形成的ICc通过兴奋性和抑制性输入之间的相互作用，收敛在it.Here，我们回顾的研究，说明了占主导地位的作用抑制ICc。我们开始通过回顾调谐曲线的研究，并显示如何抑制形状的各种调谐曲线在ICc通过边带抑制。然后，我们将展示如何抑制形状的选择性响应特性复杂的信号，专注于频率调制（FM）的扫描方向的选择性。在最后一节中，我们考虑来自体内全细胞记录的结果，该结果显示传入的激发和抑制的参数如何相互作用以形成方向选择性。我们发现，不同的信号诱发的突触后电位（PSP）可以是相似的，但引起显着不同的尖峰计数。在这些情况下，尖峰阈值充当非线性放大器，将PSP中的微小差异转换为尖峰输出中的较大差异。细胞的输入与来自同一细胞的输出之间的这种差异表明，高度选择性的放电特性可以通过对由一个或两个信号诱发的突触强度的微小调整来创建。这些研究结果还表明，可塑性的反应功能可能会实现远低于修改电路比以前假设的。
Almost all of the processing that occurs in the various lower auditory nuclei converges upon a common target in the central nucleus of the inferior colliculus (ICc) thus making the ICc the nexus of the auditory system. A variety of new response properties are formed in the ICc through the interactions among the excitatory and inhibitory inputs that converge upon it. Here we review studies that illustrate the dominant role inhibition plays in the ICc. We begin by reviewing studies of tuning curves and show how inhibition shapes the variety of tuning curves in the ICc through sideband inhibition. We then show how inhibition shapes selective response properties for complex signals, focusing on selectivity for the sweep direction of frequency modulations (FM). In the final section we consider results from in vivo whole-cell recordings that show how parameters of the incoming excitation and inhibition interact to shape directional selectivity. We show that post-synaptic potentials (PSPs) evoked by different signals can be similar but evoke markedly different spike-counts. In these cases, spike threshold acts as a non-linear amplifier that converts small differences in PSPs into large differences in spike output. Such differences between the inputs to a cell compared to the outputs from the same cell suggest that highly selective discharge properties can be created by only minor adjustments in the synaptic strengths evoked by one or both signals. These findings also suggest that plasticity of response features may be achieved with far less modifications in circuitry than previously supposed.
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