The effect of topical local anesthetics on thermal pain sensitivity in patients with irritable bowel syndrome.
The effect of topical local anesthetics on thermal pain sensitivity in patients with irritable bowel syndrome.
复制标题
局部麻醉药对肠易激综合征患者热痛敏感性的影响。
DOI：
10.1155/2012/438674
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发表时间：
2012
影响因子：
--
通讯作者：
Mauderli,AndreP
中科院分区：
文献类型：
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作者：
Rodrigues,Anthony;King,ChristopherD;Wong,Fong;Riley3rd,JosephL;Schmidt,Siegfried;Mauderli,AndreP
在肠易激综合征（IBS）患者中，延伸到躯体区域的全身性超敏反应是常见的。敏化状态，特别是通过实验方法评估，已知甚至在临床疼痛缓解期间持续存在。据推测，肠道中与疾病相关的伤害性活动维持了一种全身致敏状态。本研究评估了在恒定温度或恒定疼痛强度下对长时间热刺激的反应。局部应用直肠利多卡因对热敏性的影响也进行了评价。问题是，用利多卡因沉默潜在的肠道神经活动（可能并不总是导致有意识的疼痛体验）是否会减弱躯体区域的敏化。还进行了利多卡因口服试验，以控制药物的全身或安慰剂效应。与对照组相比，IBS受试者对躯体热刺激表现出更大的敏感性；然而，利多卡因对IBS患者的致敏性没有明显的影响，其中大多数个体在测试当天没有临床疼痛。
Generalized hypersensitivity that extends into somatic areas is common in patients with irritable bowel syndrome (IBS). The sensitized state, particularly assessed by experimental methods, is known to persist even during remissions of clinical pain. It was hypothesized that disease‐related nociceptive activity in the gut maintains a systemic‐sensitized state. The present study evaluated responses to prolonged thermal stimuli maintained at constant temperature or constant pain intensity during stimulation. The effect of topically applied rectal lidocaine on heat sensitivity was also evaluated. The question is whether silencing potential intestinal neural activity (which may not always lead to a conscious pain experience) with lidocaine attenuates sensitization of somatic areas. Tests were also performed where lidocaine was applied orally to control for systemic or placebo effects of the drug. The IBS subjects exhibited a greater sensitivity to somatic heat stimuli compared to controls; however, lidocaine had no discernible effect on sensitization in this sample of IBS patients, where most of the individuals did not have clinical pain on the day of testing.