Electrical Induction of Ventricular Fibrillation for Resuscitation From Postcountershock Pulseless and Asystolic Cardiac Arrests
Electrical Induction of Ventricular Fibrillation for Resuscitation From Postcountershock Pulseless and Asystolic Cardiac Arrests
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心室颤动的电感应用于反休克后无脉性和心搏停止性心脏骤停的复苏
作者：
Charles T. Leng;R. Berger;H. Calkins;A. Lardo;N. Paradis;Henry R. Halperin
Background—There is increasing evidence that defibrillation from prolonged ventricular fibrillation (VF) before CPR decreases survival. It remains unclear, however, whether harmful effects are due primarily to initial countershock of ischemic myocardium or to resultant postdefibrillation rhythms (ie, pulseless electrical activity [PEA] or asystole). Methods and Results—We induced 15 dogs into 12 minutes of VF and randomized them to 3 groups. Group 1 was defibrillated at 12 minutes and then administered advanced cardiac life support (ACLS); group 2 was allowed to remain in VF and was subsequently defibrillated after 4 minutes of ACLS; group 3 was defibrillated at 12 minutes, electrically refibrillated, and then defibrillated after 4 minutes of ACLS. All group 1 and 3 animals were defibrillated into PEA/asystole at 12 minutes. After 4 minutes of ACLS, group 2 and 3 animals were effectively defibrillated into sinus rhythm. The extension of VF in group 2 and 3 subjects paradoxically resulted in shorter mean resuscitation times (251±15 and 245±7 seconds, respectively, versus 459±66 seconds for group 1;P <0.05) and improved 1-hour survival (10 of 10 group 2 and 3 dogs versus 1 of 5 group 1 dogs; Fisher’s exact, P <0.005) compared with more conservatively managed group 1 subjects. Conclusions—Precountershock CPR during VF appears more conducive to resuscitation than CPR during postcountershock PEA or asystole. The intentional induction of VF may prove useful in the management of PEA and asystolic arrests.
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影响因子：
158.5
作者：
HALPERIN, HR;TSITLIK, JE;GUERCI, AD
通讯作者：
GUERCI, AD
心电图在确定长期心室颤动后反电击后机电分离犬模型中心脏复苏结果中的预测价值。
影响因子：
6.2
作者：
Niemann,JT;Garner,D;Pelikan,PC;Jagels,G
通讯作者：
Jagels,G
培养心肌细胞中的胞质钙阶梯。
影响因子：
20.1
作者：
Lee,HC;Clusin,WT
通讯作者：
Clusin,WT
反休克后无脉节律：对心肺复苏、人工心脏起搏和肾上腺素能激动剂的反应。
影响因子：
6.2
作者：
Niemann,JT;Haynes,KS;Garner,D;Rennie3rd,CJ;Jagels,G;Stormo,O
通讯作者：
Stormo,O
心脏骤停期间机电分离的预测因子。
影响因子：
6.2
作者：
Sutton-Tyrrell,K;Abramson,NS;Safar,P;Detre,K;Kelsey,SF;Monroe,J;Reinmuth,O;Mullie,A;Vandevelde,K;Hedstrand,U
通讯作者：
Hedstrand,U