High fucoxanthin wakame (Undaria pinnatifida) prevents tumor microenvironment formation in an AOM/DSS mouse carcinogenic model
High fucoxanthin wakame (Undaria pinnatifida) prevents tumor microenvironment formation in an AOM/DSS mouse carcinogenic model
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DOI：
10.1016/j.jff.2019.103709
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发表时间：
2020
影响因子：
5.6
通讯作者：
Masaru Terasaki;Y. Kuramitsu;M. Kojoma;Sang-Yong Kim;Takuji Tanaka;Hayato Maeda;K. Miyashita;Chikara Kawagoe;S. Kohno;M. Mutoh
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文献类型：
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作者：
Masaru Terasaki;Y. Kuramitsu;M. Kojoma;Sang-Yong Kim;Takuji Tanaka;Hayato Maeda;K. Miyashita;Chikara Kawagoe;S. Kohno;M. Mutoh
岩藻黄质（Fx）是裙带菜（裙带菜）中的主要叶黄素，是一种有效的类胡萝卜素，具有抗癌作用。然而，高岩藻黄素（Fx-高）裙带菜本身的癌症预防功能尚未得到很好的研究。因此，我们培养了FX高裙带菜，并研究了这种藻类对AOM/DSS致癌小鼠模型的影响。与没有裙带菜的小鼠相比，Fx高裙带菜（Fx 30 mg/kg体重）显著减少了构成肿瘤微环境的细胞的数量。结直肠癌干细胞样CD 44 high/EpCAM high细胞、癌相关成纤维细胞样α SMA high细胞、肿瘤相关巨噬细胞样和树突状细胞样CD 206 high细胞的数量分别显著减少0.6、0.5和0.5倍，凋亡细胞样切割的caspase-3 high细胞显著增加1.7倍。此外，唾液甘氨酸被Fx高裙带菜降低0.4倍。我们的研究结果表明，Fx-高裙带菜可以防止肿瘤微环境的形成与Fx-高裙带菜功能的唾液预测。
Fucoxanthin (Fx) is a major xanthophyll inUndaria pinnatifida(wakame) and is one of the potent carotenoids against cancer development. However, the cancer preventive function of high fucoxanthin (Fx-high) wakame itself has not been well investigated. Therefore, we cultivated Fx-high wakame and investigated the effect of this alga on a AOM/DSS carcinogenesis mouse model. Fx-high wakame (Fx 30 mg/kg body weight) significantly decreased the number of cells that compose the tumor microenvironment compared to mice without wakame. The number of colorectal cancer stem cell-like CD44high/EpCAMhighcells, cancer-associated fibroblast-like αSMAhighcells, tumor-associated macrophage-like and dendritic cell-like CD206highcells were significantly decreased 0.6-, 0.5-, and 0.5-fold, respectively, and apoptotic cell-like cleaved caspase-3highcells were significantly increased 1.7-fold by Fx-high wakame. Moreover, salivary glycine was decreased 0.4-fold by Fx-high wakame. Our results imply that Fx-high wakame could prevent formation of the tumor microenvironment with a salivary predictor of the Fx-high wakame function.