Photoacoustic and ultrasound imaging using dual contrast perfluorocarbon nanodroplets triggered by laser pulses at 1064 nm
Photoacoustic and ultrasound imaging using dual contrast perfluorocarbon nanodroplets triggered by laser pulses at 1064 nm
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DOI：
10.1364/boe.5.003042
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发表时间：
2014-09-01
影响因子：
3.4
通讯作者：
Emelianov, Stanislav Y.
中科院分区：
文献类型：
--
作者：
Hannah, Alexander S.;VanderLaan, Donald;Emelianov, Stanislav Y.
最近，一个双重的光声和超声造影剂-光声纳米液滴-已被引入。光声纳米液滴由全氟化碳核、表面活性剂壳和封装的光吸收剂组成。在脉冲激光照射时，全氟化碳转化为气体，从蒸发中诱导光声信号，随后从所得的气体微泡中诱导超声对比。在这项工作中，我们合成纳米液滴封装金纳米棒的峰值吸收近1064 nm。这种纳米液滴对于扩展的光声成像深度和对比度、安全性和系统成本是最佳的。我们表征了纳米液滴的光学吸收、图像对比度和蒸发阈值。然后，我们对离体猪组织样本中的颗粒进行成像，报告生物环境中的对比度增强。这些1064 nm可重复的光声纳米液滴是一种强大的生物医学工具，可增强临床相关深度的图像对比度。(C)2014年美国光学学会
Recently, a dual photoacoustic and ultrasound contrast agent-named photoacoustic nanodroplet-has been introduced. Photoacoustic nanodroplets consist of a perfluorocarbon core, surfactant shell, and encapsulated photoabsorber. Upon pulsed laser irradiation the perfluorocarbon converts to gas, inducing a photoacoustic signal from vaporization and subsequent ultrasound contrast from the resulting gas microbubbles. In this work we synthesize nanodroplets which encapsulate gold nanorods with a peak absorption near 1064 nm. Such nanodroplets are optimal for extended photoacoustic imaging depth and contrast, safety and system cost. We characterized the nanodroplets for optical absorption, image contrast and vaporization threshold. We then imaged the particles in an ex vivo porcine tissue sample, reporting contrast enhancement in a biological environment. These 1064 nm triggerable photoacoustic nanodroplets are a robust biomedical tool to enhance image contrast at clinically relevant depths. (C) 2014 Optical Society of America