Prostate squamous cell carcinoma developing 11 years after external radiotherapy for prostate adenocarcinoma.
Prostate squamous cell carcinoma developing 11 years after external radiotherapy for prostate adenocarcinoma.
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DOI：
10.1002/iju5.12161
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发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Ukimura O
中科院分区：
文献类型：
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作者：
Matsugasumi T;Nakanishi H;Yokota T;Shiraishi T;Ukimura O
前列腺癌放射治疗后继发性膀胱癌、结肠癌和直肠癌相对常见。然而，继发性前列腺鳞状细胞癌是罕见的。患者为85岁男性，以排尿困难和血清前列腺特异性抗原水平低为主诉。他的病史包括11年前接受三维适形放射治疗和雄激素剥夺治疗的局限性前列腺癌(Gleason评分4+5)。尿道镜和磁共振成像显示前列腺尿路周围有隆起的肿块。经尿道前列腺电切术病理诊断为鳞状细胞癌。本文报告1例罕见的前列腺癌放射治疗后继发前列腺癌病例，在放疗11年后发现，症状为排尿困难，包括尿路迟疑、排尿困难、排尿疼痛和血清前列腺特异性抗原水平降低。
Secondary bladder, colon, and rectal cancers are relatively common after prostate radiotherapy. However, secondary squamous cell carcinoma of the prostate is rare. An 85‐year‐old man presented with dysuria and low‐serum prostate‐specific antigen levels. His medical history included localized prostate adenocarcinoma (Gleason score of 4 + 5) treated with combined three‐dimensional conformal radiotherapy and androgen deprivation therapy, 11 years ago. Urethroscopy and magnetic resonance imaging showed a bulging mass around the prostatic urethra. Transurethral resection of the prostate performed for histopathological diagnosis revealed squamous cell carcinoma. Hereby, a rare case of secondary squamous cell carcinoma of the prostate after radiotherapy for adenocarcinoma was reported, which was found after 11 years of radiotherapy with symptom of dysuria including urinary hesitancy, difficulty, pain during urination, and low‐serum prostate‐specific antigen levels.