Silylation enhancement of photodynamic activity of tetraphenylporphyrin derivative
Silylation enhancement of photodynamic activity of tetraphenylporphyrin derivative
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DOI：
10.1016/j.jphotochem.2011.04.032
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发表时间：
2011-06-10
影响因子：
4.3
通讯作者：
Hiratsuka, Hiroshi
中科院分区：
文献类型：
--
作者：
Horiuchi, Hiroaki;Kameya, Takehiro;Hiratsuka, Hiroshi
研究了水溶性硅烷化四苯基卟啉衍生物的单线态氧增感作用。与未硅化化合物相比，硅化化合物的单线态氧敏化量子产率有所提高。为了阐明这种改善的机理，我们研究了光物理过程。硅基化增加了导致单线态氧形成的三重态猝灭的比例，从而提高了单线态氧敏化的量子产率。为了证明硅烷化化合物适合作为光动力疗法中的光敏剂用于癌症的光动力治疗，进行了人癌细胞系的细胞培养研究。我们发现硅化化合物表现出比非硅化化合物更高的光动力活性。我们认为，这种高活性是由于单线态氧敏化的量子产率和细胞摄取效率的提高所致。我们强调，通过硅烷化提高了亲油性，这在很大程度上有助于提高卟啉衍生物的细胞摄取效率。(C)2011爱思唯尔B.V.保留所有权利。
Singlet oxygen sensitization of the water-soluble silylated tetraphenylporphyrin derivative has been studied. Quantum yield of singlet oxygen sensitization of the silylated compound was improved compared with that of the non-silylated one. To clarify the mechanism of the improvement, photophysical processes have been studied. The silylation increased the fraction of the triplet state quenched responsible for the formation of singlet oxygen, and resultantly, this effect improved the quantum yield of singlet oxygen sensitization. To demonstrate the silylated compound suitable for a photosensitizer in photodynamic therapy for cancer, a cell culture study was carried out with a human cancer cell line. We found that the silylated compound displayed much higher photodynamic activity than the non-silylated one. We conclude that this high activity was caused by the improvements of both quantum yield of singlet oxygen sensitization and cellular uptake efficiency. We emphasize that improved lipophilicity by silylation contributes much to the high cellar uptake efficiency of porphyrin derivatives. (C) 2011 Elsevier B.V. All rights reserved.