Ceruloplasmin Levels in Cancer Tissues and Urine Are Significant Biomarkers of Pathological Features and Outcome in Bladder Cancer
Ceruloplasmin Levels in Cancer Tissues and Urine Are Significant Biomarkers of Pathological Features and Outcome in Bladder Cancer
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DOI：
10.21873/anticanres.15174
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发表时间：
2021-08-01
影响因子：
2
通讯作者：
Ohyama, Kaname
中科院分区：
文献类型：
--
作者：
Mukae, Yuta;Ito, Hidenori;Ohyama, Kaname
背景/目的：先前的研究表明尿中的免疫复合物-铜蓝蛋白（CP）与膀胱癌（BC）的癌变和恶性行为有关。我们研究了BC患者尿液和组织中CP蛋白水平的病理意义和预后作用。材料和方法：采用酶联免疫吸附法测定97例患者的尿CP水平。应用免疫组织化学方法对176例患者的BC组织进行CP表达评价。结果：尿CP水平与非肌肉浸润性BC （NMIBC）的肿瘤分级和pT分期呈正相关。BC组织中CP的表达与肿瘤的生长和进展呈正相关。多因素分析表明，高尿CP水平是NMIBC尿路复发的独立预测因子（风险比=2.87,p=0.016）。结论：尿CP水平是判断NMIBC恶性潜能和预后的有效生物标志物。
Background/Aim: Alpha previous report showed that immune complex-ceruloplasmin (CP) in urine is associated with carcinogenesis and malignant behavior in bladder cancer (BC). We investigated the pathological significance and prognostic roles of urine and tissue levels of CP protein in BC patients. Materials and Methods: Urine CP levels were measured using an enzyme-linked immunosorbent assay in 97 patients. CP expression in BC tissues was evaluated by immunohistochemical analysis in 176 patient samples. Results: Urine CP levels were positively associated with tumor grade and pT stage in non-muscle invasive BC (NMIBC). CP expression in BC tissues was positively associated with tumor growth and progression. Multivariate analysis demonstrated that high urine CP levels was an independent predictor of recurrence in the urinary tract in NMIBC (hazard ratio=2.87, p=0.016). Conclusion: CPrelated markers, especially urine CP levels, are useful biomarkers of malignant potential and prognosis in NMIBC.