Preliminary study of frontal lobe 1H MR spectroscopy in childhood-onset schizophrenia.
Preliminary study of frontal lobe 1H MR spectroscopy in childhood-onset schizophrenia.
复制标题
儿童期精神分裂症额叶 1H 磁共振波谱的初步研究。
DOI：
10.1002/jmri.1880080413
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
McCracken,J
中科院分区：
文献类型：
--
作者：
Thomas,MA;Ke,Y;Levitt,J;Caplan,R;Curran,J;Asarnow,R;McCracken,J
Cerebral1H MR spectra were recorded in 13 children and adolescents with schizophrenia and 12 healthy children and adolescents. Stimulated echo acquisition mode (STEAM) sequence was used to localize an 8‐ml voxel bilaterally in the frontal gray matter. The frontal gray matter metabolite ratios for NAA/Cr, Ch/Cr, Gix/Cr, and mI/Cr in schizophrenic children and adolescents were 1.08 ± .28, .64 ± .23, 1.09 ± .30, and .60 ± .24, respectively. In comparison, these ratios were 1.59 ± .35, .74 ± .27, 1.23 ± .36, and .58 ± .29 in healthy children and adolescents. Decrease in the frontal lobe NAA/Cr of schizophrenic children and adolescents was statistically significant (P < .001). In contrast, the MR spectra localized bilaterally in the occipital gray matter (8 ml) showed no significant changes between the patients and the controls. In the occipital gray matter, the metabolite ratios were 1.21 ± .26, .52 ± .08, 1.00 ± .11, and .55 ± .12 in patients versus 1.30 ± .23, .45 ± .10, 1.15 ± .20, and .48 ± .19 in controls. Our preliminary finding of reduced NAA/Cr ratio in the frontal gray matter is consistent with the neurodevelopmental models emphasizing dysfunction of frontal lobe areas in patients with schizophrenia.
