Myocardial B cells are a subset of circulating lymphocytes with delayed transit through the heart
Myocardial B cells are a subset of circulating lymphocytes with delayed transit through the heart
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DOI：
10.1172/jci.insight.134700
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发表时间：
2020-02-13
期刊：
影响因子：
8
通讯作者：
Mann, Douglas L.
中科院分区：
文献类型：
--
作者：
Adamo, Luigi;Rocha-Resende, Cibele;Mann, Douglas L.
目前的 B 淋巴细胞生物学模型认为，B 细胞在淋巴器官之间不断再循环，而不会在周围健康组织中积累。尽管如此，B 淋巴细胞是幼鼠心脏中最常见的白细胞群之一。为了调查文献中这种明显的不一致，我们对心肌 B 细胞个体发育、运输动力学、组织学和基因表达模式进行了系统分析。我们发现心肌 B 细胞代表循环 B 细胞的一个亚群，它们与心脏的微血管内皮紧密接触，并在它们通过心脏时阻止它们的转运。绝大多数 (>95%) 心肌 B 细胞保留在血管内，而很少 (
Current models of B lymphocyte biology posit that B cells continuously recirculate between lymphoid organs, without accumulating in peripheral healthy tissues. Nevertheless, B lymphocytes are one of the most prevalent leukocyte populations in the naive murine heart. To investigate this apparent inconsistency in the literature, we conducted a systematic analysis of myocardial B cell ontogeny, trafficking dynamics, histology, and gene expression patterns. We found that myocardial B cells represent a subpopulation of circulating B cells that make close contact with the microvascular endothelium of the heart and arrest their transit as they pass through the heart. The vast majority (>95%) of myocardial B cells remain intravascular, whereas few (