In contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death.
In contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death.
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发表时间：
2005
影响因子：
4.4
通讯作者：
B. Fritzsching;Nina Oberle;N. Eberhardt;S. Quick;J. Haas;B. Wildemann;P. Krammer;E. Suri‐Payer
中科院分区：
文献类型：
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作者：
B. Fritzsching;Nina Oberle;N. Eberhardt;S. Quick;J. Haas;B. Wildemann;P. Krammer;E. Suri‐Payer
CD4(+)CD25(+)FoxP3(+) 调节性 T 细胞 (T(reg)) 抑制 T 细胞功能并保护啮齿动物免受自身免疫性疾病的侵害。免疫反应期间 T(reg) 的调节非常重要。 T(reg) 存活率的提高有利于自身免疫性疾病，而细胞凋亡导致的消耗增加则有利于癌症。我们在此表明，新鲜分离的 FACS 分选的 T（reg）对 CD95 介导的细胞凋亡高度敏感，而其他 T 细胞群在分离后不久对 CD95 诱导的细胞凋亡具有抵抗力。相反，体外TCR再刺激Treg细胞显示，与CD4+CD25-T细胞相比，其对激活诱导的细胞死亡的敏感性降低。因此，与其他 T 细胞相比，T(reg) 的凋亡表型是独特的，这可能会进一步探索 T(reg) 的新治疗调节。
CD4(+)CD25(+)FoxP3(+) regulatory T cells (T(reg)) suppress T cell function and protect rodents from autoimmune disease. Regulation of T(reg) during an immune response is of major importance. Enhanced survival of T(reg) is beneficial in autoimmune disease, whereas increased depletion by apoptosis is advantageous in cancer. We show here that freshly isolated FACS-sorted T(reg) are highly sensitive toward CD95-mediated apoptosis, whereas other T cell populations are resistant to CD95-induced apoptosis shortly after isolation. In contrast, TCR restimulation of T(reg) in vitro revealed a reduced sensitivity toward activation-induced cell death compared with CD4(+)CD25(-) T cells. Thus, the apoptosis phenotype of T(reg) is unique in comparison to other T cells, and this might be further explored for novel therapeutic modulations of T(reg).