VALIDATION OF OPEN - CLOSED ARM ENTRIES IN AN ELEVATED PLUS-MAZE AS A MEASURE OF ANXIETY IN THE RAT
VALIDATION OF OPEN - CLOSED ARM ENTRIES IN AN ELEVATED PLUS-MAZE AS A MEASURE OF ANXIETY IN THE RAT
复制标题
DOI：
10.1016/0165-0270(85)90031-7
复制
发表时间：
1985-01-01
影响因子：
3
通讯作者：
BRILEY, M
中科院分区：
文献类型：
--
作者：
PELLOW, S;CHOPIN, P;BRILEY, M
描述了一种用于选择性鉴定大鼠抗焦虑和致焦虑药物作用的新试验，使用由两个开放臂和两个封闭臂组成的高架+迷宫。该试验用于检测此类药物作用的用途在行为学、生理学和生物学方面得到了验证。大鼠进入开放臂的次数明显少于进入封闭臂的次数，并且在开放臂中花费的时间明显更少。限制到开放的武器与观察到的显着更多的焦虑相关的行为，并显着更高的血浆皮质酮浓度，比限制到封闭的武器。新奇和照明都不是大鼠在+-迷宫中行为的重要因素。仅在临床有效的抗焦虑药（利血平、地西泮和效果较差的苯巴比妥）中观察到在开放臂上花费的时间百分比和进入开放臂的次数显著增加。引起人类焦虑的化合物（育亨宾、戊四唑、咖啡因、安非他明）显著降低了进入张开双臂的百分比和花费在张开双臂上的时间。抗抑郁药和主要的镇静剂都没有特定的效果。在放置在+-迷宫上之前立即暴露于洞板表明，迷宫上的行为与探索性头部浸入或自发运动活动没有明显相关性。
A novel test for the selective identification of anxiolytic and anxiogenic drug effects in the rat is described, using an elevated +-maze consisting of two open arms and two enclosed arms. The use of this test for detecting such drug effects was validated behaviorally, physiologically, and pharmacologically. Rats made significantly fewer entries into the open arms than into the closed arms, and spent significantly less time in open arms. Confinement to the open arms was associated with the observation of significantly more anxiety-related behaviors, and of significantly greater plasma corticosterone concentrations, than confinement to the closed arms. Neither novelty nor illumination was a significant contributor to the behavior of the rats on the +-maze. A significant increase in the percentage of time spent on the open arms and the number of entries into the open arms was observed only within clinically effective anxiolytics (chlordiazepoxide, diazepam and, less effectively, phenobarbitone). Compounds that cause anxiety in man significantly reduced the percentage of entries into, and time spent on, the open arms (yohimbine, pentylenetetrazole, caffeine, amphetamine). Neither antidepressants nor major tranquilizers had a specific effect. Exposure to a holeboard immediately before placement on the +-maze showed that behavior on the maze was not clearly correlated either with exploratory head-dipping or spontaneous locomotor activity.